Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts
M Hagedorn, KH Rohde, DG Russell, T Soldati - Science, 2009 - science.org
To generate efficient vaccines and cures for Mycobacterium tuberculosis, we need a far
better understanding of its modes of infection, persistence, and spreading. Host cell entry and …
better understanding of its modes of infection, persistence, and spreading. Host cell entry and …
Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis
…, T Zech, SD Calaminus, S Ura, M Hagedorn… - Journal of cell …, 2011 - rupress.org
WASP and SCAR homologue (WASH) is a recently identified and evolutionarily conserved
regulator of actin polymerization. In this paper, we show that WASH coats mature …
regulator of actin polymerization. In this paper, we show that WASH coats mature …
Flotillin and RacH modulate the intracellular immunity of Dictyostelium to Mycobacterium marinum infection
M Hagedorn, T Soldati - Cellular microbiology, 2007 - Wiley Online Library
Mycobacterium marinum, a close relative of Mycobacterium tuberculosis, provides a useful
model to study the pathogenesis of tuberculosis in genetically tractable model organisms. …
model to study the pathogenesis of tuberculosis in genetically tractable model organisms. …
Dynamic life and death interactions between Mycobacterium smegmatis and J774 macrophages
…, MG Gutierrez, H Kress, M Hagedorn… - Cellular …, 2006 - Wiley Online Library
After internalization into macrophages non‐pathogenic mycobacteria are killed within
phagosomes. Pathogenic mycobacteria can block phagosome maturation and grow inside …
phagosomes. Pathogenic mycobacteria can block phagosome maturation and grow inside …
[HTML][HTML] The ESCRT and autophagy machineries cooperate to repair ESX-1-dependent damage at the Mycobacterium-containing vacuole but have opposite impact …
…, L Gerstenmaier, C Barisch, M Hagedorn… - PLoS …, 2018 - journals.plos.org
Phagocytic cells capture and kill most invader microbes within the bactericidal phagosome,
but some pathogens subvert killing by damaging the compartment and escaping to the …
but some pathogens subvert killing by damaging the compartment and escaping to the …
Prison break: pathogens' strategies to egress from host cells
N Friedrich, M Hagedorn, D Soldati-Favre… - … and Molecular Biology …, 2012 - Am Soc Microbiol
A wide spectrum of pathogenic bacteria and protozoa has adapted to an intracellular life-style,
which presents several advantages, including accessibility to host cell metabolites and …
which presents several advantages, including accessibility to host cell metabolites and …
The autophagic machinery ensures nonlytic transmission of mycobacteria
In contrast to mechanisms mediating uptake of intracellular bacterial pathogens, bacterial
egress and cell-to-cell transmission are poorly understood. Previously, we showed that the …
egress and cell-to-cell transmission are poorly understood. Previously, we showed that the …
WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion
JS King, A Gueho, M Hagedorn… - Molecular biology of …, 2013 - Am Soc Cell Biol
Wiskott-Aldrich syndrome protein and SCAR homologue (WASH) is an important regulator of
vesicle trafficking. By generating actin on the surface of intracellular vesicles, WASH is able …
vesicle trafficking. By generating actin on the surface of intracellular vesicles, WASH is able …
Lipid droplet dynamics at early stages of Mycobacterium marinum infection in Dictyostelium
C Barisch, P Paschke, M Hagedorn… - Cellular …, 2015 - Wiley Online Library
Lipid droplets exist in virtually every cell type, ranging not only from mammals to plants, but
also to eukaryotic and prokaryotic unicellular organisms such as D ictyostelium and bacteria. …
also to eukaryotic and prokaryotic unicellular organisms such as D ictyostelium and bacteria. …
[HTML][HTML] Mycobacterium marinum antagonistically induces an autophagic response while repressing the autophagic flux in a TORC1- and ESX-1-dependent manner
…, F Bach, O Schaad, JS King, M Hagedorn… - PLoS …, 2017 - journals.plos.org
Autophagy is a eukaryotic catabolic process also participating in cell-autonomous defence.
Infected host cells generate double-membrane autophagosomes that mature in …
Infected host cells generate double-membrane autophagosomes that mature in …