Simple Summary Children with metastatic solid tumors typically have a very poor prognosis,
especially when the cancer returns or is resistant to upfront treatment. There is hope that the …

Exome sequencing has markedly enhanced the discovery of genes implicated in Mendelian
disorders, particularly for individuals in whom a known clinical entity could not be assigned. …

Programmed cell death protein 1 (PD-1) has become one of the most investigated targets for
cancer immunotherapy. Most research has centered on inhibiting PD-1 on T cells, but there …

Targeting the JAK/STAT and BCL2 pathways in patients with relapsed/refractory T cell acute
lymphoblastic leukemia (T-ALL) may provide an alternative approach to achieve clinical …

Management for high-risk neuroblastoma (NBL) has included autologous hematopoietic
stem cell transplant (HSCT) and anti-GD2 immunotherapy, but survival remains around 50%. …

Background Osteosarcoma (OS) patients that present with metastatic disease have a poor
prognosis and no curative options. Allogeneic bone marrow transplant (alloBMT) is curative …

Abstract 2536 Methods to expand natural killer (NK) cells ex vivo for adoptive cell therapy
are being explored to improve outcomes after allogeneic blood and marrow transplant (…

We evaluated the healing potential of human fetal aorta-derived CD133 + progenitor cells
and their conditioned medium (CD133 + CCM) in a new model of ischemic diabetic ulcer. …

This study compared the acute and chronic response of circulating plasma brain-derived
neurotrophic factor (BDNF) to high-intensity low-volume (HI) and low-intensity high volume (HV…

… cells during mitosis (M). S phase and mitosis are separated by Gap phases, G1 and G2. …
due to DTX halting cell division at G2/M phase and preventing redistribution (Figure 2b). …