Molecular alterations in genes involved in DNA mismatch repair (MMR) promote cancer
initiation and foster tumour progression 1 . Cancers deficient in MMR frequently show favourable …

The efficacy of KRAS G12C inhibitors in NSCLC and colorectal cancer is lineage-specific.
RTK dependency and signaling rebound kinetics are responsible for sensitivity or resistance …

Vitamin C (VitC) is known to directly impair cancer cell growth in preclinical models, but
there is little clinical evidence on its antitumoral efficacy. In addition, whether and how VitC …

Understanding immune responses to SARS-CoV-2 messenger RNA (mRNA) vaccines is of
great interest, principally because of the poor knowledge about the mechanisms of protection…

Targeting HER2 is effective in 24% of ERBB2 amplified metastatic colorectal cancer; however,
secondary resistance occurs in most of the cases. We studied the evolution of individual …

Purpose: Defects in the homologous recombination (HR) repair pathway are of clinical interest
due to sensitivity of HR-deficient cells to PARP inhibitors. We were interested in defining …

Purpose: Patient-derived xenograft (PDX) models accurately recapitulate the tumor of origin
in terms of histopathology, genomic landscape, and therapeutic response, but some …

The long-term efficacy of the Epidermal Growth Factor Receptor (EGFR)-targeted antibody
cetuximab in advanced colorectal cancer (CRC) patients is limited by the emergence of drug-…

Background Neoantigens that arise as a consequence of tumor-specific mutations can be
recognized by T lymphocytes leading to effective immune surveillance. In colorectal cancer (…

Background The analysis of circulating free tumour DNA (ctDNA) in blood, commonly
referred as liquid biopsy, is being used to characterise patients with solid cancers. Tumour-specific …