User profiles for Monica Schenone
Monica SchenonePfizer Verified email at pfizer.com Cited by 7287 |
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells
Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell neoplasms,
but its mechanism of action is unknown. Using quantitative proteomics, we found that …
but its mechanism of action is unknown. Using quantitative proteomics, we found that …
Selective killing of cancer cells by a small molecule targeting the stress response to ROS
Malignant transformation, driven by gain-of-function mutations in oncogenes and loss-of-function
mutations in tumour suppressor genes, results in cell deregulation that is frequently …
mutations in tumour suppressor genes, results in cell deregulation that is frequently …
Target identification and mechanism of action in chemical biology and drug discovery
M Schenone, V Dančík, BK Wagner… - Nature chemical …, 2013 - nature.com
Target-identification and mechanism-of-action studies have important roles in small-molecule
probe and drug discovery. Biological and technological advances have resulted in the …
probe and drug discovery. Biological and technological advances have resulted in the …
Phenotypic drug discovery: recent successes, lessons learned and new directions
F Vincent, A Nueda, J Lee, M Schenone… - Nature Reviews Drug …, 2022 - nature.com
Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …
normal or disease physiology. For the past generation, this phenotypic drug discovery …
Identifying the proteins to which small-molecule probes and drugs bind in cells
SE Ong, M Schenone, AA Margolin… - Proceedings of the …, 2009 - National Acad Sciences
Most small-molecule probes and drugs alter cell circuitry by interacting with 1 or more
proteins. A complete understanding of the interacting proteins and their associated protein …
proteins. A complete understanding of the interacting proteins and their associated protein …
The NORAD lncRNA assembles a topoisomerase complex critical for genome stability
The human genome contains thousands of long non-coding RNAs 1 , but specific biological
functions and biochemical mechanisms have been discovered for only about a dozen 2 , 3 , …
functions and biochemical mechanisms have been discovered for only about a dozen 2 , 3 , …
WRN helicase is a synthetic lethal target in microsatellite unstable cancers
…, E Reznichenko, L Leung, M Alimova, M Schenone… - Nature, 2019 - nature.com
Synthetic lethality—an interaction between two genetic events through which the co-occurrence
of these two genetic events leads to cell death, but each event alone does not—can be …
of these two genetic events leads to cell death, but each event alone does not—can be …
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9
Impaired erythropoiesis in the deletion 5q (del(5q)) subtype of myelodysplastic syndrome (MDS)
has been linked to heterozygous deletion of RPS14, which encodes the ribosomal …
has been linked to heterozygous deletion of RPS14, which encodes the ribosomal …
The blood coagulation cascade
M Schenone, BC Furie, B Furie - Current opinion in hematology, 2004 - journals.lww.com
Continued progress in this field offers opportunity for understanding the basis of thrombotic
diseases and bleeding disorders, with the potential for defining novel targets for therapeutic …
diseases and bleeding disorders, with the potential for defining novel targets for therapeutic …
[HTML][HTML] Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms
Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European
descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the …
descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the …