User profiles for Monica Schenone

Monica Schenone

Pfizer
Verified email at pfizer.com
Cited by 7287

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

…, X Li, C Ciarlo, E Hartman, N Munshi, M Schenone… - Science, 2014 - science.org
Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell neoplasms,
but its mechanism of action is unknown. Using quantitative proteomics, we found that …

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

L Raj, T Ide, AU Gurkar, M Foley, M Schenone, X Li… - Nature, 2011 - nature.com
Malignant transformation, driven by gain-of-function mutations in oncogenes and loss-of-function
mutations in tumour suppressor genes, results in cell deregulation that is frequently …

Target identification and mechanism of action in chemical biology and drug discovery

M Schenone, V Dančík, BK Wagner… - Nature chemical …, 2013 - nature.com
Target-identification and mechanism-of-action studies have important roles in small-molecule
probe and drug discovery. Biological and technological advances have resulted in the …

Phenotypic drug discovery: recent successes, lessons learned and new directions

F Vincent, A Nueda, J Lee, M Schenone… - Nature Reviews Drug …, 2022 - nature.com
Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …

Identifying the proteins to which small-molecule probes and drugs bind in cells

SE Ong, M Schenone, AA Margolin… - Proceedings of the …, 2009 - National Acad Sciences
Most small-molecule probes and drugs alter cell circuitry by interacting with 1 or more
proteins. A complete understanding of the interacting proteins and their associated protein …

The NORAD lncRNA assembles a topoisomerase complex critical for genome stability

…, CP Fulco, V Subramanian, J Chen, M Schenone… - Nature, 2018 - nature.com
The human genome contains thousands of long non-coding RNAs 1 , but specific biological
functions and biochemical mechanisms have been discovered for only about a dozen 2 , 3 , …

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

…, E Reznichenko, L Leung, M Alimova, M Schenone… - Nature, 2019 - nature.com
Synthetic lethality—an interaction between two genetic events through which the co-occurrence
of these two genetic events leads to cell death, but each event alone does not—can be …

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

RK Schneider, M Schenone, MV Ferreira, R Kramann… - Nature medicine, 2016 - nature.com
Impaired erythropoiesis in the deletion 5q (del(5q)) subtype of myelodysplastic syndrome (MDS)
has been linked to heterozygous deletion of RPS14, which encodes the ribosomal …

The blood coagulation cascade

M Schenone, BC Furie, B Furie - Current opinion in hematology, 2004 - journals.lww.com
Continued progress in this field offers opportunity for understanding the basis of thrombotic
diseases and bleeding disorders, with the potential for defining novel targets for therapeutic …

[HTML][HTML] Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms

…, CB Clish, SA Carr, BK Wagner, M Schenone… - Cell, 2017 - cell.com
Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European
descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the …