User profiles for Monika Perez
 | Monika W. PerezBioinformatician, Boston Children's Hosptial Verified email at childrens.harvard.edu Cited by 58 |
[PDF][PDF] An oncogenic enhancer encodes selective selenium dependency in AML
Deregulation of transcription is a hallmark of acute myeloid leukemia (AML) that drives
oncogenic expression programs and presents opportunities for therapeutic targeting. By …
oncogenic expression programs and presents opportunities for therapeutic targeting. By …
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia
Acute myeloid leukemia with KMT2A (MLL) rearrangements is characterized by specific
patterns of gene expression and enhancer architecture, implying unique core transcriptional …
patterns of gene expression and enhancer architecture, implying unique core transcriptional …
Transcriptional plasticity drives leukemia immune escape
Our findings point to an adaptive transcriptional mechanism of AML evolution after allogeneic
transplantation whereby combinatorial fluctuations of TF expression under immune …
transplantation whereby combinatorial fluctuations of TF expression under immune …
[HTML][HTML] Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors
Attenuating aberrant transcriptional circuits holds great promise for the treatment of
numerous diseases, including cancer. However, development of transcriptional inhibitors is …
numerous diseases, including cancer. However, development of transcriptional inhibitors is …
[HTML][HTML] Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops
Lineage-defining transcription factors form densely interconnected circuits in chromatin
occupancy assays, but the functional significance of these networks remains underexplored. We …
occupancy assays, but the functional significance of these networks remains underexplored. We …
Contrast sensitivity, visual acuity and the effect of behavioural state on optokinetic gain in fiddler crabs
M Perez, ZM Bagheri, C Brown… - Journal of …, 2023 - journals.biologists.com
Most animals rely on visual information for a variety of everyday tasks. The information available
to a visual system depends in part on its spatial resolving power and contrast sensitivity. …
to a visual system depends in part on its spatial resolving power and contrast sensitivity. …
Defining the transcriptional control of pediatric AML highlights RARA as a superenhancer-regulated druggable dependency
Somatic mutations are rare in pediatric acute myeloid leukemia (pAML), indicating that
alternate strategies are needed to identify targetable dependencies. We performed the first …
alternate strategies are needed to identify targetable dependencies. We performed the first …
[HTML][HTML] Rara is a druggable super-enhancer regulated dependency in pediatric AML
AS Daramola, M Perez, OS Sias-Garcia, MS Terrell… - Blood, 2019 - Elsevier
Introduction: New approaches to find and then drug pediatric acute myeloid leukemia (AML)-specific
targets are clearly needed to help the nearly 35% of patients who still die from the …
targets are clearly needed to help the nearly 35% of patients who still die from the …
Designing Oligonucleotide-Based FISH Probe Sets with PaintSHOP
MW Perez, CK Camplisson, BJ Beliveau - Fluorescence In Situ …, 2024 - Springer
Fluorescent in situ hybridization (FISH) enables the visualization of the position and abundance
of nucleic acid molecules in fixed cell and tissue samples. Many FISH-based methods …
of nucleic acid molecules in fixed cell and tissue samples. Many FISH-based methods …
Eviction Behaviour in the Kalahari Meerkats
M Perez - 2022 - repository.cam.ac.uk
Evictions are common in a substantial number of social species, yet they have seldom been
studied in detail, and we know relatively little about the causes and consequences of eviction…
studied in detail, and we know relatively little about the causes and consequences of eviction…