User profiles for Monsef Benkirane
monsef benkiraneDirecteur de recherche CNRS Verified email at igh.cnrs.fr Cited by 17217 |
SAMHD1 is the dendritic-and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
…, A Yatim, S Emiliani, O Schwartz, M Benkirane - Nature, 2011 - nature.com
The primate lentivirus auxiliary protein Vpx counteracts an unknown restriction factor that
renders human dendritic and myeloid cells largely refractory to HIV-1 infection 1 , 2 , 3 , 4 , 5 , 6 …
renders human dendritic and myeloid cells largely refractory to HIV-1 infection 1 , 2 , 3 , 4 , 5 , 6 …
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
SAMHD1 restricts the infection of dendritic and other myeloid cells by human immunodeficiency
virus type 1 (HIV-1), but in lentiviruses of the simian immunodeficiency virus of sooty …
virus type 1 (HIV-1), but in lentiviruses of the simian immunodeficiency virus of sooty …
Suppression of microRNA-silencing pathway by HIV-1 during virus replication
…, J Reynes, P Corbeau, KT Jeang, M Benkirane - Science, 2007 - science.org
MicroRNAs (miRNAs) are single-stranded noncoding RNAs of 19 to 25 nucleotides that
function as gene regulators and as a host cell defense against both RNA and DNA viruses. We …
function as gene regulators and as a host cell defense against both RNA and DNA viruses. We …
[HTML][HTML] Post-activation turn-off of NF-κB-dependent transcription is regulated by acetylation of p65
…, C Sardet, DY Jin, S Emiliani, M Benkirane - Journal of Biological …, 2003 - ASBMB
NF-κB represents a family of eukaryotic transcription factors participating in the regulation of
various cellular genes involved in the immediate early processes of immune, acute-phase, …
various cellular genes involved in the immediate early processes of immune, acute-phase, …
[PDF][PDF] Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing
Y Bennasser, SY Le, M Benkirane, KT Jeang - Immunity, 2005 - cell.com
In plants and invertebrate animals, RNA silencing is a form of nucleic acid-based adaptive
immunity. By contrast, jawed vertebrates have evolved complex protein-based adaptive …
immunity. By contrast, jawed vertebrates have evolved complex protein-based adaptive …
[HTML][HTML] HIV‐1 tat transcriptional activity is regulated by acetylation
…, A Burny, Y Nakatani, KT Jeang, M Benkirane… - The EMBO …, 1999 - embopress.org
The human immunodeficiency virus (HIV) trans‐activator protein, Tat, stimulates transcription
from the viral long‐terminal repeats (LTR) through an RNA hairpin element, trans‐…
from the viral long‐terminal repeats (LTR) through an RNA hairpin element, trans‐…
[HTML][HTML] Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5Δ32
M Benkirane, DY Jin, RF Chun, RA Koup… - Journal of Biological …, 1997 - ASBMB
Human chemokine receptor 5 (CCR5) functions as a co-receptor for Human immunodeficiency
virus (HIV-1) infection. CCR5 is a seven-transmembrane cell surface receptor. Recently, …
virus (HIV-1) infection. CCR5 is a seven-transmembrane cell surface receptor. Recently, …
International AIDS Society global scientific strategy: towards an HIV cure 2016
…, SR Lewin, AL Ross, J Ananworanich, M Benkirane… - Nature medicine, 2016 - nature.com
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …
global population of more than 35 million people living with HIV, there is intense interest in …
[PDF][PDF] Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1
…, B Descours, ALC Valadao, N Laguette, M Benkirane - Cell reports, 2013 - cell.com
SAMHD1 restricts HIV-1 replication in myeloid and quiescent CD4 + T cells. Here, we show
that SAMHD1 restriction activity is regulated by phosphorylation. SAMHD1 interacts with …
that SAMHD1 restriction activity is regulated by phosphorylation. SAMHD1 interacts with …
Selective CXCR4 antagonism by Tat: Implications for in vivo expansion of coreceptor use by HIV-1
…, C Neuveut, HL Tiffany, M Benkirane… - Proceedings of the …, 2000 - National Acad Sciences
Chemokines and chemokine receptors play important roles in HIV-1 infection and tropism.
CCR5 is the major macrophage-tropic coreceptor for HIV-1 whereas CXC chemokine receptor …
CCR5 is the major macrophage-tropic coreceptor for HIV-1 whereas CXC chemokine receptor …