RNA 5-methyl and 5-propynyl pyrimidine analogs were substituted into short interfering RNAs
(siRNAs) to probe major groove steric effects in the active RNA-induced silencing complex …

Phosphorothioates (PS) have proven their effectiveness in the area of therapeutic oligonucleotides
with applications spanning from cancer treatment to neurodegenerative disorders. …

We combine molecular dynamics, statistical mechanics, and hybrid quantum mechanics/molecular
mechanics simulations to describe mechanistically the severe acute respiratory …

North bicyclo methanocarba thymidine (T N ) nucleosides were substituted into siRNAs to
investigate the effect of bicyclo[3.1.0]hexane 2′‐deoxy‐pseudosugars on RNA interference …

DNAzymes have become attractive due to their potential biomedical and biotechnological
applications, as well as their advantages in terms of stability, efficiency and synthetic …

Chemical modifications aimed at stabilizing the interaction between the 3′-end of siRNAs
and the PAZ domain of RISC have been tested for their effect on RNAi activity. Such …

The i-motif is an intriguing non-canonical DNA structure, whose role in the cell is still
controversial. Development of methods to study i-motif formation under physiological conditions in …

Among the FDA approved drugs for the treatment of AIDS, non‐nucleoside reverse transcriptase
inhibitors (NNRTIs) are essential components of first‐line anti‐HIV‐1 therapy because …

Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization
of RNAs with peptides still remains a challenge. Here we describe a straightforward …

The understanding of the mechanisms behind nucleotide recognition by Argonaute 2, core
protein of the RNA-induced silencing complex, is a key aspect in the optimization of small …