The targeted pathogen-selective approach to drug development holds promise to minimize
collateral damage to the beneficial microbiome. The AB 5 -topology pertussis toxin (PtxS1-S5…

Protein ADP-ribosylation is a reversible post-translational modification, which alters protein
activity, localization, interactome or stability, leading to perturbation of cell signaling. This …

Post-translational modifications (PTMs) are one of the most important regulatory mechanisms
in cells, and they play key roles in cell signaling both in health and disease. PTM …

… and special thanks to Moona for the everlasting patience to my never-ending and untimely
questions. … This work was done with the contribution of Master Moona Miettinen and hence the …

Proteases are a group of enzymes with a catalytic function to hydrolyze peptide bonds of
proteins. Proteases regulate the activity, signaling mechanism, fate, and localization of many …

Bringing a new drug to the market is an expensive and long process. Typically, more than ten
years and a billion dollars needs to be spent so the whole process is a big investment for a …

Background During the COVID-19 pandemic multiple vaccines were rapidly developed and
widely used throughout the world. At present there is very little information on COVID-19 …

As SARS-CoV-2 has been circulating for over a year, dozens of vaccine candidates are under
development or in clinical use. The BNT162b2 mRNA COVID-19 vaccine induces spike …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
has raised concern about increased transmissibility, infectivity, and immune evasion from a …

Bordetella pertussis is the causative agent of whooping cough, a highly contagious respiratory
disease. Pertussis toxin (PT), a major virulence factor secreted by B. pertussis, is an AB5-…