Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …

Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions
in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we …

Antiaging therapies show promise in model organism research. Translation to humans is
needed to address the challenges of an aging global population. Interventions to slow human …

Biological age (BA) is useful for examining differences in aging rates. Nevertheless, little
consensus exists regarding optimal methods for calculating BA. The aim of this study is to …

Ferrucci et al Time and the Metrics of Aging 741 disease, and all-cause mortality, although
the causal nature of these associations and whether telomere shortening affects the aging …

Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed cause
of ageing is the accumulation of epigenetic noise that disrupts gene expression patterns, …

Estimates of biological age based on DNA methylation patterns, often referred to as “epigenetic
age”,“DNAm age”, have been shown to be robust biomarkers of age in humans. We …

Objectives Concepts such as Allostatic Load, Framingham Risk Score, and Biological Age
were developed to combine information from multiple measures into a single latent variable …

Behavioral and lifestyle factors have been shown to relate to a number of health-related
outcomes, yet there is a need for studies that examine their relationship to molecular aging rates…

Background Epigenetic biomarkers of aging (the “epigenetic clock”) have the potential to
address puzzling findings surrounding mortality rates and incidence of cardio-metabolic …