Abstract Analysis of antibody repertoires by high-throughput sequencing is of major
importance in understanding adaptive immune responses. Our knowledge of variations in the …

The adaptive immune receptor repertoire (AIRR) contains information on an individuals'
immune past, present and potential in the form of the evolving sequences that encode the B cell …

Introduction GATA binding protein 3 (GATA3) is a regulator of mammary luminal cell
differentiation, and an estrogen receptor (ER) associated marker in breast cancer. Tumor …

Germline variations in immunoglobulin genes influence the repertoire of B cell receptors
and antibodies, and such polymorphisms may impact disease susceptibility. However, the …

Long noncoding RNAs (lncRNAs) are major regulators of many cellular processes including
cell cycle progression and tumorigenesis. In this study, we identify a novel lncRNA, MA-linc1…

Antibody haplotype inference (chromosomal phasing) may have clinical implications for the
identification of genetic predispositions to diseases. Yet, our knowledge of the genomic loci …

Autoreactive IgA plasma cells (PCs) specific for the enzyme transglutaminase 2 (TG2) are
abundant in the small intestine of patients with active celiac disease (CD), and their number …

Inference of germline polymorphisms in immunoglobulin genes from B cell receptor
repertoires is complicated by somatic hypermutations, sequencing/PCR errors, and by varying …

The partial success of tumor immunotherapy induced by checkpoint blockade, which is not
antigen-specific, suggests that the immune system of some patients contain antigen receptors …

The role of B cells and posttranslational modifications in pathogenesis of organ-specific
immune diseases is increasingly envisioned but remains poorly understood, particularly in …