Having appropriate in vivo and in vitro systems that provide translational models for human
disease is an integral aspect of research in neurobiology and the neurosciences. Traditional …

Members of the family Herpesviridae have enveloped, spherical virions with characteristic
complex structures consisting of symmetrical and non-symmetrical components. The linear, …

Herpes simplex virus 1 (HSV-1) causes a chronic, lifelong infection in >60% of adults. Multiple
recent vaccine trials have failed, with viral diversity likely contributing to these failures. To …

The Stimulator of Interferon Genes (STING) pathway initiates potent immune responses upon
recognition of DNA. To initiate signaling, serine 365 (S365) in the C-terminal tail (CTT) of …

Herpes simplex virus 1 (HSV-1) is a well-adapted human pathogen that can invade the
peripheral nervous system and persist there as a lifelong latent infection. Despite their ubiquity, …

Alphaherpesviruses are widespread in the human population, and include herpes simplex
virus 1 (HSV-1) and 2, and varicella zoster virus (VZV). These viral pathogens cause …

Until fairly recently, genome-wide evolutionary dynamics and within-host diversity were
more commonly examined in the context of small viruses than in the context of large double-…

Virulence determines the impact a pathogen has on the fitness of its host, yet current understanding
of the evolutionary origins and causes of virulence of many pathogens is surprisingly …

Human alpha herpesviruses herpes simplex virus (HSV-1) and varicella zoster virus (VZV)
establish latency in various cranial nerve ganglia and often reactivate in response to stress-…

Increasing attention has focused on the contributions of persistent microbial infections with
the manifestation of disease later in life, including neurodegenerative conditions such as …