Normal differentiation and induced reprogramming require the activation of target cell programs
and silencing of donor cell programs 1 , 2 . In reprogramming, the same factors are often …

Direct lineage reprogramming represents a remarkable conversion of cellular and
transcriptome states 1 , 2 , 3 . However, the intermediate stages through which individual cells …

Direct conversion of nonneural cells to functional neurons holds great promise for
neurological disease modeling and regenerative medicine. We previously reported rapid …

Long intergenic noncoding RNAs (lincRNAs) are derived from thousands of loci in mammalian
genomes and are frequently enriched in transposable elements (TEs). Although families …

10.7554/eLife.40197.001 Direct reprogramming of fibroblasts to neurons induces widespread
cellular and transcriptional reconfiguration. Here, we characterized global epigenomic …

Approaches to differentiating pluripotent stem cells (PSCs) into neurons currently face two
major challenges—(i) generated cells are immature, with limited functional properties; and (ii) …

Nuclear pore complexes (NPCs) are large proteinaceous channels embedded in the nuclear
envelope (NE), through which exchange of molecules between the nucleus and cytosol …

Mitosis in metazoa requires nuclear envelope (NE) disassembly and reassembly. NE
disassembly is driven by multiple phosphorylation events. Mitotic phosphorylation of the protein …

Cell lineage specification is accomplished by a concerted action of chromatin remodeling
and tissue-specific transcription factors. However, the mechanisms that induce and maintain …

The nuclear lamina is essential for the structural integration of the nuclear envelope. Nuclear
envelope rupture and chromatin externalization is a hallmark of the formation of neutrophil …