Welchen Regeln unterliegt die wissenschaftliche Praxis? Welche grundsätzlichen Fragen
wirft die Forschung am Menschen auf? Unter welchen Bedingungen ist diese ethisch legitim? …

Modified parental histones are segregated symmetrically to daughter DNA strands during
replication and can be inherited through mitosis. How this may sustain the epigenome and cell …

A multitude of histone chaperones are required to support histones from their biosynthesis
until DNA deposition. They cooperate through the formation of histone co-chaperone …

Background: Acute infection is a well-established risk factor of cardiovascular inflammation
increasing the risk for a cardiovascular complication within the first weeks after infection. …

Cells have evolved an elaborate DNA repair network to ensure complete and accurate DNA
replication. Defects in these repair machineries can fuel genome instability and drive …

Chromatin structure and function is regulated by reader proteins recognizing histone
modifications and/or histone variants. We recently identified that PWWP2A tightly binds to H2A.Z-…

Alteration of epigenetic modifications plays an important role in human cancer. Notably, the
dysregulation of histone post-translational modifications (PTMs) has been associated with …

Human stem cells bear a great potential for multiple therapeutic applications but at the
same time constitute a major threat to human health in the form of cancer stem cells. The …

Histone N termini undergo diverse post‐translational modifications that significantly extend
the information potential of the genetic code. Moreover, these modifications mark specific …

XRCC2 genetic variants have been associated with breast cancer susceptibility. However,
association studies have been complicated because XRCC2 variants are extremely rare and …