Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting
protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is …

Inflammasomes are one of the most important mechanisms for innate immune defense
against microbial infection but are also known to drive various inflammatory disorders via …

Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin-1 (IL-1)
receptor-dependent, caspase-1-independent inflammatory disease. Conditional …

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in …

Inflammation is a healthy response to infection or danger and should be rapid, specific and
terminated once the threat has passed. Inflammatory diseases, where this regulation fails, …

The exposure of phosphatidylserine (PS) on the outer plasma membrane has long been
considered a unique feature of apoptotic cells. Together with other “eat me” signals, it enables …

Upon ligand binding, RIPK1 is recruited to tumor necrosis factor receptor superfamily (TNFRSF)
and Toll-like receptor (TLR) complexes promoting prosurvival and inflammatory …

RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to
cause inflammation via the release of intracellular molecules. Whether and how RIPK3 might …

Although microRNA (miRNA) regulation of TLR signaling is well established, this has not yet
been observed for NLR proteins or the inflammasomes they form. We have now validated a …

Cytopenias are key prognostic indicators of life-threatening infection, contributing to
immunosuppression and mortality. Here we define a role for Caspase-1-dependent death, known as …