p53-mediated increase in cyclin-dependent kinase inhibitor p21 WAF1 protein is thought to
be the major mediator of cell cycle arrest after DNA damage. Previously p21 protein levels …

Abstract Development of selective kinase inhibitors that target the ATP binding site
continues to be a challenge largely due to similar binding pockets. Palbociclib is a cyclin-dependent …

UV or gamma irradiation mediated DNA damage activates p53 and induces cell cycle arrest.
Induction of cyclin-dependent kinase inhibitor p21WAF1 by p53 after DNA damage plays …

Recently, we reported the purification to homogeneity and characterization of Ca 2+ - and Mg
2+ -dependent endonuclease P40 produced by Mycoplasma penetrans (M. Bendjennat, A. …

HIV virions assemble on the plasma membrane and bud out of infected cells using
interactions with endosomal sorting complexes required for transport (ESCRTs). HIV protease …

Polymerization of Gag on the inner leaflet of the plasma membrane drives the assembly of
Human Immunodeficiency Virus 1 (HIV-1). Gag recruits components of the endosomal sorting …

The major nuclease from Mycoplasma penetrans has been purified to homogeneity. The
enzyme seems to be present as a membrane-associated precursor of 50 kDa and as a …

Developing small molecules that indirectly regulate Mcl-1 function has attracted a lot of
attention in recent years. Here, we report the discovery of an aminopyrazole, 2-([1,1′-biphenyl]-4…

Myotonic dystrophy types 1 and 2 (DM1 and DM2) are forms of muscular dystrophy that share
similar clinical and molecular manifestations, such as myotonia, muscle weakness, cardiac …

Kaposi's sarcoma herpesvirus (KSHV) is an angiogenesis-inducing oncovirus whose ability
to usurp the oxygen-sensing machinery is central to its oncogenicity. By upregulating the …