Mesenchymal stem cells (MSC) are multipotent cells that differentiate into osteoblasts,
myocytes, chondrocytes and adipocytes as well as insulin-producing cells. The mechanism …

During pancreatic islet development, sequential changes in gene expression are known to
be necessary for efficient differentiation and function of the endocrine pancreas. Several …

There is a global diabetes epidemic correlating with an increase in obesity. This coincidence
may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained …

Telomeres are regions of repetitive nucleotide sequences at the ends of chromosomes.
Telomere length is a marker of DNA damage, which is often considered a biomarker for …

The mammalian pancreas is known to show a remarkable degree of regenerative ability.
Several studies until now have demonstrated that the mammalian pancreas can regenerate in …

Epithelial-to-mesenchymal transition is a phenomenon necessary for embryonic development
and also seen during certain pathological conditions. We show here for the first time that …

The ability to detect glucose concentrations in human urine offers a non-invasive approach
to monitor changes in blood glucose, kidney health and vascular complications associated …

Background aims. The scarcity of human islets for transplantation remains a major limitation
of cell replacement therapy for diabetes. Bone marrow-derived progenitor cells are of …

OBJECTIVE Several studies support associations between relative leukocyte telomere
length (rLTL), a biomarker of biological aging and type 2 diabetes. This study investigates the …

People in developing countries have faced multigenerational undernutrition and are currently
undergoing major lifestyle changes, contributing to an epidemic of metabolic diseases, …