Tractography based on non-invasive diffusion imaging is central to the study of human brain
connectivity. To date, the approach has not been systematically validated in ground truth …

Background Serum neurofilament light chain (sNfL) is a biomarker of neuronal damage that
is used not only to monitor disease activity and response to drugs and to prognosticate …

Diffusion MRI fiber tractography is widely used to probe the structural connectivity of the brain,
with a range of applications in both clinical and basic neuroscience. Despite widespread …

White matter bundle segmentation using diffusion MRI fiber tractography has become the
method of choice to identify white matter fiber pathways in vivo in human brains. However, like …

Damage to the myelin sheath and the neuroaxonal unit is a cardinal feature of multiple
sclerosis; however, a detailed characterization of the interaction between myelin and axon …

Objectives Neuropathological studies have shown that multiple sclerosis (MS) lesions are
heterogeneous in terms of myelin/axon damage and repair as well as iron content. However, it …

Importance The mechanisms driving neurodegeneration and brain atrophy in relapsing
multiple sclerosis (RMS) are not completely understood. Objective To determine whether …

Importance There is a lack of validated biomarkers for disability progression independent of
relapse activity (PIRA) in multiple sclerosis (MS). Objective To determine how serum glial …

Diffusion magnetic resonance imaging is a noninvasive imaging modality that has been
extensively used in the literature to study the neuronal architecture of the brain in a wide range …

The presence of cortical lesions in multiple sclerosis patients has emerged as an important
biomarker of the disease. They appear in the earliest stages of the illness and have been …