Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are intermediate states
in glucose metabolism that exist between normal glucose tolerance and overt diabetes. …

Insulin resistance in skeletal muscle is manifested by decreased insulin-stimulated glucose
uptake and results from impaired insulin signaling and multiple post-receptor intracellular …

Chronic hyperglycemia impairs insulin action, resulting in glucotoxicity, which can be ameliorated
in animal models by inducing glucosuria with renal glucose transport inhibitors. Here, …

This study was conducted to observe changes in insulin secretion and insulin action in
subjects with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). A total of …

OBJECTIVE—To derive indexes for muscle and hepatic insulin sensitivity from the measurement
of plasma glucose and insulin concentrations during an oral glucose tolerance test (…

Hyperglycemia plays an important role in the pathogenesis of type 2 diabetes mellitus, i.e.,
glucotoxicity, and it also is the major risk factor for microvascular complications. Thus, …

The kidney has a pivotal role in maintaining glucose homeostasis by using glucose as a
metabolic fuel, by producing glucose through gluconeogenesis, and by reabsorbing all filtered …

OBJECTIVE Fibroblast growth factor (FGF)-21 is highly expressed in the liver and regulates
hepatic glucose production and lipid metabolism in rodents. However, its role in the …

OBJECTIVE—We sought to assess insulin secretion/insulin resistance index in predicting
the risk for future type 2 diabetes RESEARCH DESIGN AND METHODS—A total of 1,551 …

Individuals with impaired glucose tolerance (IGT) and/or impaired fasting glucose (IFG) are
at high risk, not only to develop diabetes mellitus, but also to experience an adverse …