[HTML][HTML] Screens in fly and beetle reveal vastly divergent gene sets required for developmental processes

MS Hakeemi, S Ansari, M Teuscher, M Weißkopf… - BMC biology, 2022 - Springer
Background Most of the known genes required for developmental processes have been
identified by genetic screens in a few well-studied model organisms, which have been …

Fog signaling has diverse roles in epithelial morphogenesis in insects

…, C von Levetzow, D Stappert, MS Hakeemi… - Elife, 2019 - elifesciences.org
… We propose two possible scenarios for Fog’s role in PGC internalization in Tribolium.
One possibility is that PGC localization is due to a requirement for Fog signaling within the …

A Large Scale Systemic RNAi Screen in the Red Flour Beetle Tribolium castaneum Identifies Novel Genes Involved in Insect Muscle Development

…, U Majumdar, MS Hakeemi… - G3: Genes …, 2019 - academic.oup.com
Although muscle development has been widely studied in Drosophila melanogaster there
are still many gaps in our knowledge, and it is not known to which extent this knowledge can …

[HTML][HTML] The role of natural products and their multitargeted approach to treat solid cancer

N Muhammad, D Usmani, M Tarique, H Naz, M Ashraf… - Cells, 2022 - mdpi.com
Natural products play a critical role in the discovery and development of numerous drugs for
the treatment of various types of cancer. These phytochemicals have demonstrated anti-…

Temporal restriction of RNAi reveals breakdown of the segmentation clock is reversible after knock down of primary pair rule genes but not Wnt-signaling in the red …

F Kaufholz, JC Ulrich, MS Hakeemi, G Bucher - bioRxiv, 2023 - biorxiv.org
Animals from all major clades have evolved a segmented trunk, reflected for instance in the
repetitive organization of the human spine or the insect segments. These units emerge …

Large portion of essential genes is missed by screening either fly or beetle indicating unexpected diversity of insect gene function

MS Hakeemi, S Ansari, M Teuscher, M Weißkopf… - bioRxiv, 2021 - biorxiv.org
Most gene functions were detected by screens in very few model organisms but it has remained
unclear how comprehensive these data are. Here, we expanded our RNAi screen in the …

[HTML][HTML] Phenotypic screen and transcriptomics approach complement each other in functional genomics of defensive stink gland physiology

…, M Weißkopf, S Ansari, M Teuscher, MS Hakeemi… - BMC genomics, 2022 - Springer
Background Functional genomics uses unbiased systematic genome-wide gene disruption
or analyzes natural variations such as gene expression profiles of different tissues from …

[HTML][HTML] Incidence, clinical features, and outcomes of posterior circulation ischemic stroke: insights from a large multiethnic stroke database

…, N Akhtar, S Kamran, S Al Jerdi, A Muhammad… - Frontiers in …, 2024 - frontiersin.org
… The higher representation of men in our cohort mirrors Qatar’s demographic skew toward
men, primarily influenced by a significant presence of able-bodied South Asian blue-collar …

Fog signaling has diverse roles in epithelial morphogenesis in insects

…, C von Levetzow, D Stappert, MS Hakeemi… - bioRxiv, 2019 - biorxiv.org
… We propose two possible scenarios for Fog’s role in PGC internalization in Tribolium.
One possibility is that PGC localization is due to a requirement for Fog signaling within the …

[HTML][HTML] Experimental investigation of hybrid beams utilizing ultra-high performance concrete (UHPC) as tension reinforcement

IY Hakeem, MK Rahman, F Althoey - Materials, 2022 - mdpi.com
Ultra-high performance concrete (UHPC) is a new generation concrete with extremely high
tensile and compressive strength, high durability, and ductility. UHPC offers tremendous …