Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 …
Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …
Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants
PURPOSE To provide precise age-specific risk estimates of cancers other than female breast
and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for …
and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for …
Prevalence of BRCA1 and BRCA2 mutations in Pakistani breast and ovarian cancer patients
Among Asian countries, Pakistan has the highest rates of breast and ovarian cancer. To
assess the contribution of the BRCA1 and BRCA2 germ line mutations to these high rates, we …
assess the contribution of the BRCA1 and BRCA2 germ line mutations to these high rates, we …
[HTML][HTML] Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer
…, R Bjork Barkardottir, U Hamann, MU Rashid… - PLoS …, 2011 - journals.plos.org
Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization
is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of …
is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of …
Characterization of the cancer spectrum in men with germline BRCA1 and BRCA2 pathogenic variants: results from the consortium of investigators of modifiers of …
Importance The limited data on cancer phenotypes in men with germlineBRCA1 and
BRCA2pathogenic variants (PVs) have hampered the development of evidence-based …
BRCA2pathogenic variants (PVs) have hampered the development of evidence-based …
[PDF][PDF] Influence of glass fibers on mechanical properties of concrete with recycled coarse aggregates
Despite plain cement concrete presenting inferior performance in tension and adverse
environmental impacts, it is the most widely used construction material in the world. Consumption …
environmental impacts, it is the most widely used construction material in the world. Consumption …
Breast cancer risk factors and survival by tumor subtype: pooled analyses from the Breast Cancer Association Consortium
…, D Plaseska-Karanfilska, N Presneau, MU Rashid… - … , biomarkers & prevention, 2021 - AACR
Background: It is not known whether modifiable lifestyle factors that predict survival after
invasive breast cancer differ by subtype. Methods: We analyzed data for 121,435 women …
invasive breast cancer differ by subtype. Methods: We analyzed data for 121,435 women …
Family history, genetic testing, and clinical risk prediction: pooled analysis of CHEK2* 1100delC in 1,828 bilateral breast cancers and 7,030 controls
…, EN Imyanitov, U Hamann, MU Rashid… - … Biomarkers & Prevention, 2009 - AACR
If breast cancers arise independently in each breast the odds ratio (OR) for bilateral breast
cancer for carriers of CHEK2*1100delC should be ∼5.5, the square of the reported OR for a …
cancer for carriers of CHEK2*1100delC should be ∼5.5, the square of the reported OR for a …
Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers
…, H Ehrencrona, D Torres, MU Rashid… - Human molecular …, 2011 - academic.oup.com
Mutations in the BRCA1 gene substantially increase a woman's lifetime risk of breast cancer.
However, there is great variation in this increase in risk with several genetic and non-…
However, there is great variation in this increase in risk with several genetic and non-…
Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan
MU Rashid, N Muhammad, S Faisal, A Amin… - Breast Cancer Research …, 2014 - Springer
RAD51C plays a key role in homologous recombination-mediated DNA repair and
maintenance of genomic stability. Biallelic RAD51C mutations cause Fanconi anemia, and …
maintenance of genomic stability. Biallelic RAD51C mutations cause Fanconi anemia, and …