Gastrulation controls the emergence of cellular diversity and axis patterning in the early
embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the …

How position-dependent cell fate acquisition occurs during embryogenesis is a central
question in developmental biology. To study this process, we developed a defined, high-…

New fundamental discoveries in stem cell biology have yielded potentially transformative
regenerative therapeutics. However, widespread implementation of stem-cell-derived …

In vitro models of postimplantation human development are valuable to the fields of regenerative
medicine and developmental biology. Here, we report characterization of a robust in …

The mechanism by which morphogenetic signals engage the regulatory networks responsible
for early embryonic tissue patterning is incompletely understood. Here, we developed a …

Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a
potentially powerful tool for investigating the relationship between genetic variants and cellular …

Stem cell renewal and differentiation are regulated by interactions with the niche. Although
multiple cell populations have been identified in distinct anatomical compartments, little is …

Efforts to recapitulate haematopoiesis, a process guided by spatial and temporal inductive
signals, to generate haematopoietic progenitors from human pluripotent stem cells (hPSCs) …

The balance between stem cell renewal and differentiation is determined by the interplay
between intrinsic cellular controls and extrinsic factors presented by the microenvironment, or ‘…

Quantitative analysis of human induced pluripotent stem cell (iPSC) lines from healthy donors
is a powerful tool for uncovering the relationship between genetic variants and cellular …