The commonly used eye-specific sev-GAL4 and GMR-GAL4 drivers in Drosophila melanogaster are expressed in tissues other than eyes also
M Ray, SC Lakhotia - Journal of genetics, 2015 - Springer
The binary GAL4-UAS system of conditional gene expression is widely used by Drosophila
geneticists to target expression of the desired transgene in tissue of interest. In many studies, …
geneticists to target expression of the desired transgene in tissue of interest. In many studies, …
Sex-specific splicing occurs genome-wide during early Drosophila embryogenesis
M Ray, AM Conard, J Urban, P Mahableshwarkar… - Elife, 2023 - elifesciences.org
Sex-specific splicing is an essential process that regulates sex determination and drives
sexual dimorphism. Yet, how early in development widespread sex-specific transcript diversity …
sexual dimorphism. Yet, how early in development widespread sex-specific transcript diversity …
The large noncoding hsrω-n transcripts are essential for thermotolerance and remobilization of hnRNPs, HP1 and RNA polymerase II during recovery from heat shock …
SC Lakhotia, M Mallik, AK Singh, M Ray - Chromosoma, 2012 - Springer
The hs-GAL4 t -driven expression of the hsrω-RNAi transgene or EP93D allele of the
noncoding hsrω resulted in global down- or upregulation, respectively, of the large hsrω-n …
noncoding hsrω resulted in global down- or upregulation, respectively, of the large hsrω-n …
Over-expression of Hsp83 in grossly depleted hsrω lncRNA background causes synthetic lethality and l(2)gl phenocopy in Drosophila
M Ray, S Acharya, S Shambhavi, SC Lakhotia - Journal of biosciences, 2019 - Springer
We examined interactions between the 83 kDa heat-shock protein (Hsp83) and hsrω long
noncoding RNAs (lncRNAs) in hsrω 66 Hsp90GFP homozygotes, which almost completely …
noncoding RNAs (lncRNAs) in hsrω 66 Hsp90GFP homozygotes, which almost completely …
Activated Ras/JNK driven Dilp8 in imaginal discs adversely affects organismal homeostasis during early pupal stage in Drosophila, a new checkpoint for …
M Ray, SC Lakhotia - Developmental Dynamics, 2019 - Wiley Online Library
Background Dilp8‐mediated inhibition of ecdysone synthesis and pupation in holometabolous
insects maintains developmental homeostasis through stringent control of timing and …
insects maintains developmental homeostasis through stringent control of timing and …
Altered levels of hsromega lncRNAs further enhance Ras signaling during ectopically activated Ras induced R7 differentiation in Drosophila
M Ray, G Singh, SC Lakhotia - Gene expression patterns, 2019 - Elsevier
We exploited the high Ras activity induced differentiation of supernumerary R7 cells in
Drosophila eyes to examine if hsrω lncRNAs influence active Ras signaling. Surprisingly, either …
Drosophila eyes to examine if hsrω lncRNAs influence active Ras signaling. Surprisingly, either …
Dual DNA/RNA-binding factor regulates dynamics of hnRNP splicing condensates
M Ray, J Zaborowsky, P Mahableshwarkar… - bioRxiv, 2024 - biorxiv.org
Despite decades of research, mechanisms by which co-transcriptional alternative splicing
events are targeted to the correct genomic locations to drive cell fate decisions remain …
events are targeted to the correct genomic locations to drive cell fate decisions remain …
Getting started: altering promoter choice as a mechanism for cell type differentiation
M Ray, E Larschan - Genes & Development, 2020 - genesdev.cshlp.org
In this issue of Genes & Development, Lu and colleagues (pp. 663–677) have discovered a
key new mechanism of alternative promoter choice that is involved in differentiation of …
key new mechanism of alternative promoter choice that is involved in differentiation of …
Altered hsrω lncRNA levels in activated Ras background further enhance Ras activity in Drosophila eye and induces more R7 photoreceptors
M Ray, SC Lakhotia - bioRxiv, 2017 - biorxiv.org
To examine role of hsrω nuclear lncRNAs in Ras signaling cascade, we down- or up-regulated
these transcripts in eye discs of Drosophila expressing sev-GAL4 driven activated ras …
these transcripts in eye discs of Drosophila expressing sev-GAL4 driven activated ras …
The CLAMP GA-binding transcription factor regulates heat stress-induced transcriptional repression by associating with 3D loop anchors.
In order to survive when exposed to heat stress (HS), organisms activate stress response
genes and repress constitutive gene expression to prevent the accumulation of potentially toxic …
genes and repress constitutive gene expression to prevent the accumulation of potentially toxic …