The molecular mechanisms and signalling pathways that regulate the in vitro preservation
of distinct pluripotent stem cell configurations, and their induction in somatic cells by direct …

The mammalian body plan is established shortly after the embryo implants into the maternal
uterus, and our understanding of post-implantation developmental processes remains …

Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by ectopic expression
of different transcription factors, classically Oct4 (also known as Pou5f1), Sox2, Klf4 and …

Isolating human MEK/ERK signaling-independent pluripotent stem cells (PSCs) with naive
pluripotency characteristics while maintaining differentiation competence and (epi)genetic …

The kidney plays a critical role in fluid homeostasis, glucose control, and drug excretion.
Loss of kidney function due to drug-induced nephrotoxicity affects over 20% of the adult …

The study of cardiac physiology is hindered by physiological differences between humans
and small-animal models. Here we report the generation of multi-chambered self-paced …

The epigenetic dynamics of induced pluripotent stem cell (iPSC) reprogramming in correctly
reprogrammed cells at high resolution and throughout the entire process remain largely …

Drug development is currently hampered by the inability of animal experiments to accurately
predict human response. While emerging organ on chip technology offers to reduce risk …

Background Caspases are a family of cysteinyl proteases that regulate apoptosis and other
biological processes. Caspase-3 is considered the central executioner member of this family …

The intestinal epithelium holds an immense regenerative capacity mobilized by intestinal
stem cells ( ISC s), much of it supported by Wnt pathway activation. Several unique regulatory …