User profiles for Muyun Lihan
Muyun LihanSchrödinger Verified email at schrodinger.com Cited by 276 |
Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation
The cellular membrane constitutes one of the most fundamental compartments of a living cell,
where key processes such as selective transport of material and exchange of information …
where key processes such as selective transport of material and exchange of information …
[HTML][HTML] Phosphatidic acid induces conformational changes in Sec18 protomers that prevent SNARE priming
Eukaryotic cell homeostasis requires transfer of cellular components among organelles and
relies on membrane fusion catalyzed by SNARE proteins. Inactive SNARE bundles are …
relies on membrane fusion catalyzed by SNARE proteins. Inactive SNARE bundles are …
Targeting lipid–protein interaction to treat Syk-mediated acute myeloid leukemia
Membrane lipids control the cellular activity of kinases containing the Src homology 2 (SH2)
domain through direct lipid–SH2 domain interactions. Here we report development of new …
domain through direct lipid–SH2 domain interactions. Here we report development of new …
Target‐template relationships in protein structure prediction and their effect on the accuracy of thermostability calculations
Improving protein thermostability has been a labor‐ and time‐consuming process in
industrial applications of protein engineering. Advances in computational approaches have …
industrial applications of protein engineering. Advances in computational approaches have …
Using AlphaFold and Experimental Structures for the Prediction of the Structure and Binding Affinities of GPCR Complexes via Induced Fit Docking and Free Energy …
Free energy perturbation (FEP) remains an indispensable method for computationally assaying
prospective compounds in advance of synthesis. However, before FEP can be deployed …
prospective compounds in advance of synthesis. However, before FEP can be deployed …
[PDF][PDF] Binding mode of SARS-CoV-2 fusion peptide to human cellular membrane
Infection of human cells by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)
relies on its binding to a specific receptor and subsequent fusion of the viral and host cell …
relies on its binding to a specific receptor and subsequent fusion of the viral and host cell …
[PDF][PDF] Involvement of a Conserved Intramembrane Acidic Residue in Cholesterol Binding of Mitochondrial VDAC1 Revealed by Microsecond-Scale Simulations
M Lihan, E Tajkhorshid - Biophysical Journal, 2021 - cell.com
Voltage-dependent anion channel 1 (VDAC1), a β-barrel membrane protein abundant in the
mitochondrial outer membrane, mediates the exchange of ions and metabolites between …
mitochondrial outer membrane, mediates the exchange of ions and metabolites between …
[PDF][PDF] de novo Design and in silico Optimization of Antibody-Like Binders Targeting Ebola Viral Antigen
Since the Ebola outbreak in West Africa in February 2014, there has been an urgent need of
a sensitive, rapid and reliable diagnostic tool for early detection of Ebola virus. Targeting …
a sensitive, rapid and reliable diagnostic tool for early detection of Ebola virus. Targeting …
[PDF][PDF] Binding Mode of SARS-CoV2 Fusion Peptide to Human Cellular Membranes
Infection of human cells by the SARS-CoV2 relies on its binding to a specific receptor and
subsequent fusion of the viral and the host cell membranes. The fusion peptide (FP), a short …
subsequent fusion of the viral and the host cell membranes. The fusion peptide (FP), a short …
[PDF][PDF] Investigating cholesterol dynamics and interactions with the dopamine transporter using a membrane mimetic model
M Lihan, E Tajkhorshid - Biophysical Journal, 2018 - cell.com
Cholesterol, an integral component of animal lipid membranes, is involved in modulation of
both membrane physical properties and a wide variety of membrane proteins. Conventional …
both membrane physical properties and a wide variety of membrane proteins. Conventional …