The cellular membrane constitutes one of the most fundamental compartments of a living cell,
where key processes such as selective transport of material and exchange of information …

Eukaryotic cell homeostasis requires transfer of cellular components among organelles and
relies on membrane fusion catalyzed by SNARE proteins. Inactive SNARE bundles are …

Membrane lipids control the cellular activity of kinases containing the Src homology 2 (SH2)
domain through direct lipid–SH2 domain interactions. Here we report development of new …

Improving protein thermostability has been a labor‐ and time‐consuming process in
industrial applications of protein engineering. Advances in computational approaches have …

Free energy perturbation (FEP) remains an indispensable method for computationally assaying
prospective compounds in advance of synthesis. However, before FEP can be deployed …

Infection of human cells by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)
relies on its binding to a specific receptor and subsequent fusion of the viral and host cell …

Voltage-dependent anion channel 1 (VDAC1), a β-barrel membrane protein abundant in the
mitochondrial outer membrane, mediates the exchange of ions and metabolites between …

Since the Ebola outbreak in West Africa in February 2014, there has been an urgent need of
a sensitive, rapid and reliable diagnostic tool for early detection of Ebola virus. Targeting …

Infection of human cells by the SARS-CoV2 relies on its binding to a specific receptor and
subsequent fusion of the viral and the host cell membranes. The fusion peptide (FP), a short …

Cholesterol, an integral component of animal lipid membranes, is involved in modulation of
both membrane physical properties and a wide variety of membrane proteins. Conventional …