Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …

… at the N terminus… N-terminal domain of BANK1 encoded by exon 2, whereas Lyn interacts
with the C-terminal portion 5 . Our own analysis predicts a pleckstrin homology domain in the N …

Background and objective: We explored which clinical and biochemical variables predict
conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS…

Background Genomewide association studies of autoimmune diseases have mapped hundreds
of susceptibility regions in the genome. However, only for a few association signals has …

… Of these 26 genes, 12 either contain bona fide susceptibility variants (n ¼ 3) or are located
within bona fide associated regions (n ¼ 9), representing a specificity of 46% and a sensitivity …

Multiple sclerosis (MS) is a complex demyelinating disease of the central nervous system,
presenting with different clinical forms, including clinically isolated syndrome (CIS), which is a …

Multiple sclerosis is a complex neurological disease, with ∼20% of risk heritability attributable
to common genetic variants, including >230 identified by genome-wide association …

We assembled and analyzed genetic data of 47,351 multiple sclerosis (MS) subjects and
68,284 control subjects and establish a reference map of the genetic architecture of MS that …

… in any of the 1000genomes, dbSNP, ExAC or ESP database (N in.db = 6359) with those not
annotated in any public database (N novel = 12780), we found a disproportionate number of …

Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system
characterized by chronic inflammation, demyelination, and axonal damage. As microRNA (…