The causes of childhood cancer have been systematically studied for several decades, but
apart from high-dose radiation and prior chemotherapy there are few or no strong external …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

… These estimates have been derived from mostly North American and Northern European
populations; the G2019S mutation seems to be extremely rare in East Asia. Nevertheless, the …

We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six …

More than 800 published genetic association studies have implicated dozens of potential
risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have …

… N Pankratz undertook statistical analyses comparing the clinical phenotype of those with
and without the PARK8 mutation and contributed to the manuscript. D Hernandez undertook …

Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …

Importance While mutations in glucocerebrosidase (GBA1) are associated with an increased
risk for Parkinson disease (PD), it is important to establish whether such mutations are also …

Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …

… (n = 7,667); (2) there were differential rates of missing genotypes in the cases and controls (n
= 75) or males and females (n … was observed in the control sample (n = 906). Many markers …