User profiles for Néstor Sampedro Vallina

Néstor Sampedro

Postdoctoral Researcher
Verified email at inano.au.dk
Cited by 36

RNA origami scaffolds facilitate cryo-EM characterization of a Broccoli–Pepper aptamer FRET pair

N Sampedro Vallina, EKS McRae… - Nucleic Acids …, 2023 - academic.oup.com
Cryogenic electron microscopy (cryo-EM) is a promising method for characterizing the structure
of larger RNA structures and complexes. However, the structure of individual aptamers is …

Structure, folding and flexibility of co-transcriptional RNA origami

…, A Bøggild, MTA Nguyen, N Sampedro Vallina… - Nature …, 2023 - nature.com
RNA origami is a method for designing RNA nanostructures that can self-assemble through
co-transcriptional folding with applications in nanomedicine and synthetic biology. However, …

An RNA paranemic crossover triangle as a 3D module for cotranscriptional nanoassembly

N Sampedro Vallina, EKS McRae, C Geary… - Small, 2023 - Wiley Online Library
RNA nanotechnology takes advantage of structural modularity to build self‐assembling
nano‐architectures with applications in medicine and synthetic biology. The use of paranemic …

An RNA origami robot that traps and releases a fluorescent aptamer

NS Vallina, EKS McRae, C Geary, ES Andersen - Science Advances, 2024 - science.org
RNA nanotechnology aims to use RNA as a programmable material to create self-assembling
nanodevices for application in medicine and synthetic biology. The main challenge is to …

Computer-Aided Design and Production of RNA Origami as Protein Scaffolds and Biosensors

NS Vallina, C Geary, M Jepsen… - DNA and RNA Origami …, 2023 - Springer
RNA nanotechnology is able to take advantage of the modularity of RNA to build a wide
variety of structures and functional devices from a common set of structural modules. The RNA …

Enzymatic assembly of small synthetic genes with repetitive elements

…, MV Gobry, N Sampedro Vallina… - ACS Synthetic …, 2024 - ACS Publications
Gene synthesis efficiency has greatly improved in recent years but is limited when it comes to
repetitive sequences, which results in synthesis failure or delays by DNA synthesis vendors…

RNA origami scaffolds as a cryo-EM tool for investigating aptamer-ligand binding of a Broccoli-Pepper FRET pair

NS Vallina, EKS McRae, BK Hansen, A Boussebayle… - bioRxiv, 2022 - biorxiv.org
RNA nanotechnology uses motifs from nature as well as aptamers from in vitro selection to
construct nanostructures and devices for applications in RNA medicine and synthetic biology. …

An RNA origami robot that traps and releases a fluorescent aptamer

N Sampedro Vallina, EKS McRae, C Geary… - bioRxiv, 2023 - biorxiv.org
RNA nanotechnology aims at using RNA as a programmable material to create self-assembling
nanodevices for application in medicine and synthetic biology. RNA devices have been …

[CITATION][C] RNA-Based Robotic Modules

NS Vallina - 2022 - pure.au.dk
Nestor Sampedro Vallina

High-resolution structures and conformational dynamics of RNA origami during folding

…, H Rasmussen, J Liu, A Bøggild, M Nguyen, N Vallina… - 2022 - researchsquare.com
Cotranscriptional folding of RNA is a fundamental self-assembly process of nature, important
for the biological assembly of complex molecular machines like the ribosome. Inspired by …