Kappa opioid receptors (KORs) in the central nervous system have been known to be important
regulators of a variety of psychiatry illnesses, including anxiety and addiction, but their …

Eating disorders are complex brain disorders that afflict millions of individuals worldwide. The
etiology of these diseases is not fully understood, but a growing body of literature suggests …

DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal
activity, and behavior. Here we used a structure-based approach to develop a new G i -…

The nucleus accumbens (NAc) and the dynorphinergic system are widely implicated in
motivated behaviors. Prior studies have shown that activation of the dynorphin-kappa opioid …

Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs).
We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during …

… Crowley et al. demonstrate that kappa opioid receptors (KORs) in the bed nucleus of the
stria terminalis (BNST) inhibit pathway-specific glutamate transmission and show optogenetic …

Chronic alcohol consumption and withdrawal leads to anxiety, escalated alcohol drinking
behavior, and alcohol dependence. Alterations in the function of key structures within the …

Recent advancements in technology have enabled researchers to probe the brain with the
greater region, cell, and receptor specificity. These developments have allowed for a more …

… During the same surgery, 200-μm diameter (NA 0.37) ferrules were bilaterally directed at
the dmPFC (coordinates relative to bregma: AP -1.9, ML ±1.0, DV -2.0, 20 angle) and …

The central nucleus of the amygdala plays a significant role in alcohol use and other affective
disorders; however, the genetically-defined neuronal subtypes and projections that govern …