Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma-cell
proliferative disorder associated with a life-long risk of progression to multiple myeloma (…

Background Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the
precise molecular alterations induced by smoking in lung that develop into cancer and …

Overwhelming evidence indicates that environmental exposures, broadly defined, are
responsible for most cancer. There is reason to believe, however, that relatively common …

Three genetic loci for lung cancer risk have been identified by genome-wide association
studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well …

Background In the National Lung Screening Trial (NLST), screening with low-dose computed
tomography (CT) resulted in a 20% reduction in lung-cancer mortality among participants …

The incidence and mortality rates of prostate cancer are significantly higher in African-American
men when compared with European-American men. We tested the hypothesis that …

Genome‐wide scans of nucleotide variation in human subjects are providing an increasing
number of replicated associations with complex disease traits. Most of the variants detected …

The wide variations in urinary bladder and colo-rectal cancer incidence in humans have
been attributed in part to metabolic factors associated with exposure to carcinogenic aromatic …

Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …

Background Otherwise healthy persons with a small number of B-cell clones circulating in
the peripheral blood have been designated as having monoclonal B-cell lymphocytosis (MBL)…