Iron–sulfur clusters are ubiquitous protein cofactors with critical cellular functions. The
mitochondrial Fe–S assembly complex, which consists of the cysteine desulfurase NFS1 and its …

The core machinery for de novo biosynthesis of iron-sulfur clusters (ISC), located in the
mitochondria matrix, is a five-protein complex containing the cysteine desulfurase NFS1 that is …

Iron–sulfur (Fe–S) clusters function as protein cofactors for a wide variety of critical cellular
reactions. In human mitochondria, a core Fe–S assembly complex [called SDUF and …

Iron–sulfur (Fe–S) clusters are essential protein cofactors for most life forms. In human
mitochondria, the core Fe–S biosynthetic enzymatic complex (called SDUF) consists of NFS1, …

Rapid evolution of enzymes provides unique molecular insights into the remarkable
adaptability of proteins and helps to elucidate the relationship between amino acid sequence, …

The mitochondrial acyl carrier protein (human ACPM, yeast Acp1) is an essential
mitochondrial protein. Through binding of nascent acyl chains on the serine (S112)-bound 4′-…

Sjögren’s syndrome (SjS) is a systemic autoimmune disease that mainly affects the exocrine
glands, leading to generalized mucosal dryness. However, primary SjS may initially present …

As SARS-CoV-2 continues to circulate, antiviral treatments are needed to complement
vaccines. The virus’s main protease, 3CLPro, is an attractive drug target in part because it …

Human de novo iron-sulfur (Fe-S) assembly complex consists of cysteine desulfurase NFS1,
accessory protein ISD11, acyl carrier protein ACP, scaffold protein ISCU, and allosteric …

Objective To develop and validate an international set of classification criteria for primary
Sjögren's syndrome (SS) using guidelines from the American College of Rheumatology (ACR) …