Fungi are morphologically, ecologically, metabolically, and phylogenetically diverse. They
are known to produce numerous bioactive molecules, which makes them very useful for …

Absolute Configuration of Stereogenic Centres bearing Hydroxyl Groups Distant from the
THF Rings Biological Activities

Extracts of milk thistle have been recognized for centuries as “liver tonics” and are well-known
to prevent or reverse hepatotoxicity of reactive drug metabolites or naturally occurring …

The research team of Dr. Monroe E. Wall and Dr. Mansukh C. Wani of Research Triangle
Institute discovered two first-in-class life-saving chemotherapeutic agents. Camptothecin, first …

Silymarin, also known as milk thistle extract, inhibits hepatitis C virus (HCV) infection and
also displays antioxidant, anti-inflammatory, and immunomodulatory actions that contribute to …

A biocompatible polyester dendrimer composed of the natural metabolites, glycerol and
succinic acid, is described for the encapsulation of the antitumor camptothecins, 10-…

Romidepsin (Istodax), a selective inhibitor of histone deacetylases (HDACs), was approved
for the treatment of cutaneous T-cell lymphoma in November 2009 by the US Food and Drug …

Extracts from the seeds of milk thistle, Silybum marianum, are known commonly as silibinin
and silymarin and possess anticancer actions on human prostate carcinoma in vitro and in …

… Kroll DJ, Shaw HS, Oberlies NH. Milk thistle nomenclature: why it matters in cancer … Graf
TN, Wani MC, Agarwal R, Kroll DJ, Oberlies NH. Gram-scale purification of flavonolignan …

Fourteen structurally diverse Annonaceous acetogenins, representing the three main classes
of bis-adjacent, bis-nonadjacent, and single-THF ring(s), were tested for their ability to …