User profiles for N. J. Kirkland

Natalie Kirkland

Verified email at ucsd.edu
Cited by 200

[PDF][PDF] Polarization of myosin II refines tissue material properties to buffer mechanical stress

M Duda, NJ Kirkland, N Khalilgharibi, M Tozluoglu… - Developmental cell, 2019 - cell.com
… Duda and Kirkland et al. develop a tissuestretching device and demonstrate that Myosin II
polarizes with mechanical stretch, a rapid reaction that changes tissue stiffness and elasticity …

[PDF][PDF] Planar differential growth rates initiate precise fold positions in complex epithelia

M Tozluoǧlu, M Duda, NJ Kirkland, R Barrientos… - Developmental cell, 2019 - cell.com
Tissue folding is a fundamental process that shapes epithelia into complex 3D organs. The
initial positioning of folds is the foundation for the emergence of correct tissue morphology. …

[HTML][HTML] Subcellular remodeling in filamin C deficient mouse hearts impairs myocyte tension development during progression of dilated cardiomyopathy

JD Powers, NJ Kirkland, C Liu, SS Razu… - International journal of …, 2022 - mdpi.com
Dilated cardiomyopathy (DCM) is a life-threatening form of heart disease that is typically
characterized by progressive thinning of the ventricular walls, chamber dilation, and systolic …

[PDF][PDF] Tissue mechanics regulate mitotic nuclear dynamics during epithelial development

NJ Kirkland, AC Yuen, M Tozluoglu, N Hui, EK Paluch… - Current Biology, 2020 - cell.com
… By using genetic and physical manipulations of cell packing, Kirkland et al. find a density-dependent
regulation of mitotic nuclear dynamics in the developing Drosophila wing disc. …

[BOOK][B] South Carolina schools and Goals 2000: National standards in music

NJ Kirkland - 1996 - search.proquest.com
The main purpose of this study was to evaluate South Carolina K-12 music programs in choral,
instrumental, and general music in the grade categories specified in the Standards (K-4, 5…

Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs

NJ Kirkland, SH Skalak, AJ Whitehead, JD Hocker… - Nature aging, 2023 - nature.com
As we age, structural changes contribute to progressive decline in organ function, which in
the heart act through poorly characterized mechanisms. Taking advantage of the short …

Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity

K Birker, S Ge, NJ Kirkland, JL Theis, J Marchant… - Elife, 2023 - elifesciences.org
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a
likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic …

[HTML][HTML] Community-driven online initiatives have reshaped scientific engagement

JPK Armstrong, I de Lázaro, NJ Kirkland… - Nature Reviews …, 2021 - nature.com
Scientists have reacted to COVID-19 restrictions by organizing virtual seminars and journal
clubs to maintain engagement. We reflect on our experiences and lessons learned from …

A bax-induced pro-oxidant state is critical for cytochromec release during programmed neuronal death

RA Kirkland, JA Windelborn, JM Kasprzak… - Journal of …, 2002 - Soc Neuroscience
… Pellets were next homogenized for 15–20 sec with a disposable pellet pestle (Kontes,
Vineland, NJ). The homogenized samples were boiled for 5 min and then returned to room …

[HTML][HTML] Widespread reworking of Hadean-to-Eoarchean continents during Earth's thermal peak

CL Kirkland, MIH Hartnady, M Barham… - Nature …, 2021 - nature.com
The nature and evolution of Earth’s crust during the Hadean and Eoarchean is largely unknown
owing to a paucity of material preserved from this period. However, clues may be found …