The term neurodegenerative disease refers to the principal pathology associated with
disorders such as amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease and …

Glutamate is the primary excitatory amino acid neurotransmitter in the central nervous
system and its activity is carefully modulated in the synaptic cleft by glutamate transporters. A …

The neurotoxic properties of glutamate were first demonstrated in 1957 by Lucas and
Newhouse, 1 who showed that systemic administration of glutamate to infant mice caused retinal …

Transgenic overexpression of Cu +2 /Zn +2 superoxide dismutase 1 (SOD1) harboring an
amyotrophic lateral sclerosis (ALS)-linked familial genetic mutation (SOD1 G93A ) in a …

A hexanucleotide repeat expansion (HRE), (GGGGCC) n , in C9orf72 is the most common
genetic cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and …

… We thank all members of the Maragakis and Rothstein labs for helpful discussion and K.
Tanaka for providing GLT1-null mice. This work was supported by the Robert Packard Center …

Background Tofersen is an antisense oligonucleotide that mediates the degradation of
superoxide dismutase 1 (SOD1) messenger RNA to reduce SOD1 protein synthesis. Intrathecal …

We have investigated the potential of human pluripotent cells to restore function in rats
paralyzed with a virus-induced motor neuronopathy. Cells derived from embryonic germ cells, …

Recent studies highlight astrocytes as key drivers of motor neuron (MN) degeneration and
disease propagation in mutant human superoxide dismutase 1 (mSOD1)-mediated …

Besides their capacity to give rise to neurons and/or glia, neural stem cells (NSCs) appear
to inherently secrete neurotrophic factors beneficial to injured neurons. To test this potential, …