The organization of bristles on the Drosophila notum has long served as a popular model of
robust tissue patterning. During this process, membrane-tethered Delta activates …

The biomechanical and biochemical properties of connective tissues are determined by the
composition and quality of their extracellular matrix. This, in turn, is highly dependent on the …

Cytoplasmic dynein-2 is a motor protein complex that drives the movement of cargoes along
microtubules within cilia, facilitating the assembly of these organelles on the surface of …

… min, 6–15% B over 58 min, 15–32% B over 58 min, 32–40% B over 5 min, 40–90% B over
1 min, held at 90% B for 6 min, and then reduced to 1% B over 1 min) with a flow rate of 300 nl·…

Cytoplasmic dynein-2 is the motor for retrograde intraflagellar transport (IFT), and mutations
in dynein-2 are known to cause skeletal ciliopathies. Here, we define for the first time the …

… (Acclaim PepMap) over a 120-min organic gradient with a flow rate of 300 nl/min−1. Peptides
were ionized by nano-electrospray ionization at 2.3 1 kV using a stainless steel emitter with …

The Golgi is the cellular hub for complex glycosylation, controlling accurate processing of
complex proteoglycans, receptors, ligands and glycolipids. Its structure and organisation are …

A subset of Rab GTPases have been implicated in cilium formation in cultured mammalian
cells [1–6]. Rab11 and Rab8, together with their GDP-GTP exchange factors (GEFs), TRAPP-…

10.7554/eLife.39655.001 The dynein-2 microtubule motor is the retrograde motor for
intraflagellar transport. Mutations in dynein-2 components cause skeletal ciliopathies, notably …

Complex machinery is required to drive secretory cargo export from the endoplasmic
reticulum (ER), which is an essential process in eukaryotic cells. In vertebrates, the MIA3 gene …