Effective antiretroviral therapy (ART) blunts viraemia, which enables HIV-1-infected individuals
to control infection and live long, productive lives. However, HIV-1 infection remains …

HIV latency is multifactorial and thus the eradication of HIV infection may require multiple
approaches. Translational efforts employing pharmacological methods to target HIV latency …

Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of antiretroviral
therapy (ART). To remove the stigma and burden of chronic infection, approaches to …

… Following in vitro exposure to 335 nM VOR for 6 h, HIV RNA expression was significantly
upregulated in 8 of 9 patients in whom resting CD4 + T cell HIV RNA was quantifiable without …

… PMA was tested at 2 nM in primary cell models and 16 nM in J-Lat clones. At these
concentrations, PMA elicited maximal or near-maximal responses in J-Lat cells, except in clone 8.4. …

The quantitative viral outgrowth assay (QVOA) provides a precise minimal estimate of the
reservoir of resting CD4 + T-cell infection (resting cell infection [RCI]). However, the variability …

… 500 nM), but was poorly induced by the canonical NF-κB agonist PEP005 (12 nM), the
noncanonical NF-κB agonist AZD5582 (100 nM… (200 nM raltegravir, 100 nM nevirapine and 25 nM …

Histone deacetylases (HDACs) act on histones within the nucleosome-bound promoter of
human immunodeficiency virus type 1 (HIV-1) to maintain proviral latency. HDAC inhibition …

… Synergistic effects were seen when we used a combination of 500 nM SAHA, which is a
suboptimal concentration, and 5 μM DZNep; 500 nM SAHA induced only 4.2% of the latent …

… Copy numbers of HIV RNA were normalized to the total RNA input to the cDNA reaction,
measured by absorption at 260 nm with a Nanodrop 2000 spectrometer (Thermo Scientific). …