… In this article, Funa, Schachter, and colleagues et al. provide mechanistic insights into how
Wnt signaling controls early cell lineage decisions. b-catenin occupies regulatory regions in …

Shb (Src homology 2 protein B) is an adapter protein downstream of the vascular endothelial
growth factor receptor receptor-2 (VEGFR-2). Previous experiments have suggested a role …

SHB is an Src homology 2 domain‐containing adapter protein that has been found to be
involved in numerous cellular responses. We have generated an Shb knockout mouse. No Shb …

The Shb adapter protein is an Src homology 2-domain containing signaling intermediate
operating downstream of several tyrosine kinase receptors, including vascular endothelial …

Type 1 diabetes may depend on cytokine-induced β-cell death and therefore the current
investigation was performed in order to elucidate this response in Shb-deficient islets. A …

The mechanisms controlling endodermal development during stem cell differentiation have
been only partly elucidated, although previous studies have suggested the participation of …

Genetic differences between pluripotent stem cell lines causes variable activity of extra-cellular
signaling pathways, which limits the reproducibility of directed differentiation protocols. …

Background Early detection and diagnosis of bipolar disorder can be difficult. Tools are
needed to help clinicians detect bipolar disorder earlier, which would ameliorate the prognosis. …

Adhesion molecules play a crucial role in transplant rejection in regulating the interaction of
inflammatory cells with cells in the vascular wall. In an aortic transplantation model, we have …

Peripheral blood mononuclear leucocytes (PBL) of 11 children with Down's syndrome (DS,
trisomy 21) and 13 healthy control children were examined for interferon (IFN) producing …