Tumour cell plasticity is a major barrier to the efficacy of targeted cancer therapies but the
mechanisms that mediate it are poorly understood. Here, we identify dysregulated RNA …

The number of patients diagnosed with chronic bile duct disease is increasing and in most
cases these diseases result in chronic ductular scarring, necessitating liver transplantation. …

The liver has a unique ability to regenerate 1 , 2 , however in the setting of acute liver failure
(ALF) this regenerative capacity is often overwhelmed and emergency liver transplantation …

Background & Aims In the developing liver, bipotent epithelial progenitor cells known as
hepatoblasts undergo lineage segregation to form the two major epithelial cell types, …

… NT Younger and ML Wilson contributed equally to this article. Current address for NT
Younger and DH Wilson: Centre for Inflammation Research, University of Edinburgh, Edinburgh, …

… normal NT-proBNP level has a high negative predictive value for heart failure. The use of
NT-… the prognostic value of NT-proBNP in heart failure in children younger than 3 years old and …

… Plasma NT-proBNP levels are often used as a … younger than 50 years when NT-proBNP
levels are >450 ng/L [9], and in children up to 14 years if ≥500 ng/L [10]. Higher-than-normal NT…

Cholangiopathies, or biliary diseases, account for a significant proportion of adult and
paediatric liver disease. In these pathologies, iterative cycles of damage and repair result in the …

In the developing liver, bipotent epithelial progenitor cells known as hepatoblasts undergo
lineage segregation to form the two major epithelial cell types, hepatocytes that constitute the …

Intrahepatic cholangiocarcinoma (ICC) is an aggressive and lethal malignancy of the bile
ducts within the liver characterised by high levels of genetic heterogeneity. In the context of …