FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome

…, H Lohi, S Cirera, M Fredholm, N Botherel… - Nucleic acids …, 2017 - academic.oup.com
Whole transcriptome sequencing (RNA-seq) has become a standard for cataloguing and
monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify the …

Natural models for retinitis pigmentosa: progressive retinal atrophy in dog breeds

…, C Hamel, L Lagoutte, G Manes, N Botherel… - Human Genetics, 2019 - Springer
Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal disorders eventually
leading to blindness with different ages of onset, progression and severity. Human RP, first …

Canine neuropathies: powerful spontaneous models for human hereditary sensory neuropathies

S Correard, J Plassais, L Lagoutte, N Botherel… - Human Genetics, 2019 - Springer
In humans, hereditary sensory neuropathies (HSN), also known as hereditary sensory and
autonomic neuropathies (HSAN), constitute a clinically and genetically heterogeneous group …

[HTML][HTML] Identification of common predisposing loci to hematopoietic cancers in four dog breeds

…, C Dufaure de Citres, P Devauchelle, N Botherel… - PLoS …, 2021 - journals.plos.org
Histiocytic sarcoma (HS) is a rare but aggressive cancer in both humans and dogs. The
spontaneous canine model, which has clinical, epidemiological, and histological similarities with …

[HTML][HTML] Characterisation and functional predictions of canine long non-coding RNAs

…, V Wucher, L Lagoutte, E Cadieu, N Botherel… - Scientific Reports, 2018 - nature.com
… Despite the number of tissues investigated in this study (n = 26), tissue-specificity is a
limiting factor in annotating the whole repertoire of lncRNAs of a species, since their annotation …

[HTML][HTML] A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies

…, E Guaguère, B Hédan, A Pommier, N Botherel… - PLoS …, 2016 - journals.plos.org
Human Hereditary Sensory Autonomic Neuropathies (HSANs) are characterized by insensitivity
to pain, sometimes combined with self-mutilation. Strikingly, several sporting dog breeds …

Discovery of human-similar gene fusions in canine cancers

…, J Abadie, C De Brito, JM Coindre, N Botherel… - Cancer research, 2017 - AACR
Canine cancers represent a tremendous natural resource due to their incidence and striking
similarities to human cancers, sharing similar clinical and pathologic features as well as …

[HTML][HTML] Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma

…, E Cadieu, T Derrien, C Kergal, N Botherel… - Scientific Reports, 2021 - nature.com
Circulating tumor DNA (ctDNA) has become an attractive biomarker in human oncology, and
its use may be informative in canine cancer. Thus, we used droplet digital PCR or PCR for …

[HTML][HTML] Identification of a Missense Variant in MFSD12 Involved in Dilution of Phaeomelanin Leading to White or Cream Coat Color in Dogs

B Hédan, E Cadieu, N Botherel, C Dufaure de Citres… - Genes, 2019 - mdpi.com
White coat color in mammals has been selected several times during the domestication
process. Numerous dog breeds are fixed for one form of white coat color that involves darkly …

[HTML][HTML] Genome-wide analysis of long non-coding RNA profiles in canine oral melanomas

…, E Cadieu, V Wucher, A Primot, A Prouteau, N Botherel… - Genes, 2019 - mdpi.com
… Here, we sampled a large cohort (n = 52) of canine normal/tumor oral MM from three
predisposed breeds (poodles, Labrador retrievers, and golden retrievers), and used deep …