User profiles for N. Chomont
 | Nicolas ChomontUniversité de Montréal Verified email at umontreal.ca Cited by 19973 |
International AIDS Society global scientific strategy: towards an HIV cure 2016
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …
global population of more than 35 million people living with HIV, there is intense interest in …
Immune activation and HIV persistence: implications for curative approaches to HIV infection
NR Klatt, N Chomont, DC Douek… - Immunological …, 2013 - Wiley Online Library
Despite complete or near‐complete suppression of human immunodeficiency virus ( HIV )
replication with combination antiretroviral therapy, both HIV and chronic inflammation/immune …
replication with combination antiretroviral therapy, both HIV and chronic inflammation/immune …
HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals
HIV infection can persist in spite of efficacious antiretroviral therapies. Although incomplete
inhibition of viral replication may contribute to this phenomenon, this is largely due to the …
inhibition of viral replication may contribute to this phenomenon, this is largely due to the …
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
HIV persists in a reservoir of latently infected CD4 + T cells in individuals treated with highly
active antiretroviral therapy (HAART). Here we identify central memory (T CM ) and …
active antiretroviral therapy (HAART). Here we identify central memory (T CM ) and …
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
The engagement of programmed death 1 (PD-1) to its ligands, PD-L1 and PD-L2 1 , 2 , 3 , 4
, inhibits proliferation and cytokine production mediated by antibodies to CD3 (refs. 5 , 6 , 7 ). …
, inhibits proliferation and cytokine production mediated by antibodies to CD3 (refs. 5 , 6 , 7 ). …
[HTML][HTML] Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
… (A) Heatmap showing the fold change in gene expression using linear regression analysis
between CA-US HIV RNA and DEG at two hours following the initial dose of vorinostat (n = 9). …
between CA-US HIV RNA and DEG at two hours following the initial dose of vorinostat (n = 9). …
[HTML][HTML] Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection
… = 5) compared to those at Fiebig I (median 8 copies/10 6 PBMCs, n = 7) AHI, p = 0.01 (Figure
5A). As more than 95% of the reservoir is harbored by CD4+ T cells (Chomont N, …
5A). As more than 95% of the reservoir is harbored by CD4+ T cells (Chomont N, …
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
… Participants who received VRC01 doses of 20 mg/kg (n = 3) are indicated with circular
symbols and solid lines; those who received 40 mg/kg (n = 3) are indicated with triangular …
symbols and solid lines; those who received 40 mg/kg (n = 3) are indicated with triangular …
[HTML][HTML] CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART
HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART).
Identifying cellular markers expressed at the surface of these cells may lead to novel therapeutic …
Identifying cellular markers expressed at the surface of these cells may lead to novel therapeutic …
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
…, TA Crowell, R Trichavaroj, R O'Connell, N Chomont… - Nature medicine, 2018 - nature.com
… N. Chomont designed and performed the laboratory experiments. DJC and JA led the study,
with support from EK, JI and N. Chomchey in managing the study. JA drafted the manuscript. …
with support from EK, JI and N. Chomchey in managing the study. JA drafted the manuscript. …