Pathogenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT)

…, K Aurich, K Methling, M Lalk, U Völker, N Endlich - Seminars in …, 2022 - Elsevier
… (each n = 7) and VITT patients (n = 7) at a serum dilution of 1:40. PageRuler Prestained
Protein Ladder was used (Invitrogen/Thermo Fisher) as a molecular mass standard and for the …

The challenge and response of podocytes to glomerular hypertension

N Endlich, K Endlich - Seminars in nephrology, 2012 - Elsevier
… In skeletal and smooth muscle maximum isometric tension has been measured to be
approximately 10 N/cm 2 .25, 26 Thus, skeletal or smooth muscle could generate a force of 4 nN on …

Stressed podocytes—mechanical forces, sensors, signaling and response

K Endlich, F Kliewe, N Endlich - Pflügers Archiv-European Journal of …, 2017 - Springer
… An N-terminal SH3 domain of p130Cas enables binding to several proteins, eg, to vinculin
… As soon as the p130Cas homodimer gets anchored with its N-terminal SH3 domains to focal …

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

V Teichgräber, M Ulrich, N Endlich, J Riethmüller… - Nature medicine, 2008 - nature.com
… The genetic disorder cystic fibrosis, which affects approximately 80,000 individuals in
Europe and North America, is caused by mutations in the CFTR gene 1,2,3 . Chronic microbial …

Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia

…, L Krutzke, F Siegerist, N Endlich… - Blood, The Journal …, 2021 - ashpublications.org
… Each data point represents 12 runs of n ≥3 individual measurements. Statistical assessment
by ordinary 1-way analysis of variance (ANOVA) with Sidak's multiple comparisons test. (D) …

Podocytes respond to mechanical stress in vitro

N Endlich, KR Kress, J Reiser… - Journal of the …, 2001 - journals.lww.com
… Nicole Endlich and Jochen Reiser were recipients of a postdoctoral fellowship of the “Graduiertenkolleg
Experimentelle Nieren- und Kreislaufforschung” of the “Deutsche …

Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

…, C Boucheix, X Belenfant, P Callard, N Endlich… - Nature medicine, 2011 - nature.com
… We induced albuminuria in male 129S2 mice (n = 7 per group) by intraperitoneal injection
of LPS on days 1 and 2. Mice were given erlotinib (10 mg kg −1 d −1 ) or vehicle alone before …

Genome-wide association studies identify genetic loci associated with albuminuria in diabetes

…, N Verweij, NJ Wareham, N Endlich, N Soranzo… - Diabetes, 2016 - Am Diabetes Assoc
Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic
kidney disease and are associated with an increased risk for end-stage renal disease and …

Mechanisms of angiotensin II signaling on cytoskeleton of podocytes

HH Hsu, S Hoffmann, N Endlich, A Velic… - Journal of molecular …, 2008 - Springer
… Three independent experiments were performed, and 12 cross wounds were created for
each group (n = 12). To estimate cell migration, the number of cells crossing a 1-mm wound …

Functional expression of the renin-angiotensin system in human podocytes

…, D Lang, J Bohm, N Endlich… - American Journal …, 2006 - journals.physiology.org
Experimental and clinical studies impressively demonstrate that angiotensin-converting
enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) significantly reduce …