Pan‐junctional sarcoplasmic reticulum in vascular smooth muscle: nanospace Ca2+ transport for site‐ and function‐specific Ca2+ signalling
C van Breemen, N Fameli… - The Journal of physiology, 2013 - Wiley Online Library
This review focuses on how smooth muscle sarcoplasmic reticulum (SR), the major releasable
Ca 2+ store in these cells, performs its many functions by communicating with the plasma …
Ca 2+ store in these cells, performs its many functions by communicating with the plasma …
The structure and functioning of the couplon in the mammalian cardiomyocyte
The couplons of the cardiomyocyte form nanospaces within the cell that place the L-type
calcium channel (Ca v 1.2), situated on the plasmalemma, in opposition to the type 2 ryanodine …
calcium channel (Ca v 1.2), situated on the plasmalemma, in opposition to the type 2 ryanodine …
[HTML][HTML] From contraction to gene expression: nanojunctions of the sarco/endoplasmic reticulum deliver site-and function-specific calcium signals
AM Evans, N Fameli, OA Ogunbayo, J Duan… - Science China Life …, 2016 - Springer
Calcium signals determine, for example, smooth muscle contraction and changes in gene
expression. How calcium signals select for these processes is enigmatic. We build on the “…
expression. How calcium signals select for these processes is enigmatic. We build on the “…
[HTML][HTML] Cytoplasmic nanojunctions between lysosomes and sarcoplasmic reticulum are required for specific calcium signaling
N Fameli, OA Ogunbayo, C van Breemen… - …, 2014 - ncbi.nlm.nih.gov
… parallel, then g WL = N TPC2 g TPC2 , N TPC2 is the number of complexes in that set and
g TPC2 is the single TPC2 determined as 15 pS [ 2]. We can then find N TPC2 by dividing the …
g TPC2 is the single TPC2 determined as 15 pS [ 2]. We can then find N TPC2 by dividing the …
Ca2+ signaling in smooth muscle: TRPC6, NCX, and LNats in nanodomains
D Poburko, N Fameli, KH Kuo, C van Breemen - Channels, 2008 - Taylor & Francis
Following the recent observation of localized cytosolic subplasmalemmal [Na + ] elevations (LNats)
in rat aortic smooth muscle cells, we discuss here the current evidence for the …
in rat aortic smooth muscle cells, we discuss here the current evidence for the …
A quantitative model for linking Na+/Ca2+ exchanger to SERCA during refilling of the sarcoplasmic reticulum to sustain [Ca2+] oscillations in vascular smooth muscle
N Fameli, C van Breemen, KH Kuo - Cell calcium, 2007 - Elsevier
We have developed a quantitative model for the creation of cytoplasmic Ca 2+ gradients near
the inner surface of the plasma membrane (PM). In particular we simulated the refilling of …
the inner surface of the plasma membrane (PM). In particular we simulated the refilling of …
[HTML][HTML] Na +/Ca2+ exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca2+ via ER nanojunctions in vascular endothelial cells
…, K Groschner, C van Breemen, N Fameli - … -European Journal of …, 2017 - Springer
We investigated the role of Na + / Ca 2+ exchange (NCX) in the refilling of endoplasmic
reticulum (ER) Ca 2+ in vascular endothelial cells under various conditions of cell stimulation …
reticulum (ER) Ca 2+ in vascular endothelial cells under various conditions of cell stimulation …
Mitochondria buffer NCX-mediated Ca2+-entry and limit its diffusion into vascular smooth muscle cells
D Poburko, K Potter, E van Breemen, N Fameli… - Cell calcium, 2006 - Elsevier
… = 14) and cells pre-treated for 10 min with 10 μM KB-R7943 (gray trace, n = 8). Traces
are … of KB-R on was found to be highly significant (n = 11 pairs, compared with paired t-test). …
are … of KB-R on was found to be highly significant (n = 11 pairs, compared with paired t-test). …
[HTML][HTML] Waves of Calcium Depletion in the Sarcoplasmic Reticulum of Vascular Smooth Muscle Cells: An Inside View of Spatiotemporal Ca2+ Regulation
M Esfandiarei, N Fameli, YYH Choi, AY Tehrani… - PloS one, 2013 - journals.plos.org
… A) D1SR fluorescent ratio was calibrated in situ in semi-permeabilized SMCs (n = 12 cells
from four independent culture plates, mean ± SEM) in intracellular solutions with 0.001 to 10 …
from four independent culture plates, mean ± SEM) in intracellular solutions with 0.001 to 10 …
A model for the generation of localized transient [Na+] elevations in vascular smooth muscle
N Fameli, KH Kuo, C van Breemen - Biochemical and biophysical research …, 2009 - Elsevier
… straight line distance d, and recording the number of RW steps N taken to cover d. From
diffusion theory, the total time t taken … The quantity t/N was our choice for τ and its value is 10 −11 …
diffusion theory, the total time t taken … The quantity t/N was our choice for τ and its value is 10 −11 …