Light-sheet microscopy is an ideal technique for imaging large cleared samples; however,
the community is still lacking instruments capable of producing volumetric images of …

Background: Sodium channel Nav1.7 has emerged as a target of considerable interest in
pain research, since loss-of-function mutations in SCN9A, the gene that encodes Nav1.7, are …

… Succination appears to be specific for cysteine, as we have been unable to detect
succination of other candidate nucleophilic amino acids, N-acetyllysine or N-acetylhistidine, in …

… for cyst numbers from mice in each group (n = 4). Error bars indicate ± 1 SD. … N- and C-terminal
fragment ions of both peptides are assigned in the spectrum and depicted as follows: b: N-…

We examined the ability of pyridoxamine (PM), an inhibitor of formation of advanced glycation
end products (AGEs) and lipoxidation end products (ALEs), to protect against diabetes-…

… of HLRCC tumours (n = 16) with established FH mutations. Importantly, 2SC was undetectable
in normal tissues (n = 200) and tumour types not associated with HLRCC (n = 1342). In a …

… Succination of other amino acids was not detectable in vivo nor in incubations of N-acetyllysine
or N-acetylhistidine with fumarate at neutral or alkaline pH. Further, incubation of bovine …

… Sequencing revealed no germline or somatic FH alterations in 14 tumors that either exhibited
only cytoplasmic 2SC staining (n= 5) or were negative for 2SC (n= 9), despite their HLRCC-…

… Serum-free medium containing sRAGE with 6× histidine at the N-terminal was subjected to
purification with Ni-NTA agarose gel. The final product produced a single band of ∼40 kDa in …

… In these studies [10], in order to normalize CMC to the free cysteine content of protein, we
originally proposed to measure total free sulfhydryl groups in protein by reaction with N-(ethyl)…