Families of zinc metalloproteases

NM Hooper - FEBS letters, 1994 - Wiley Online Library
… This family includes mammalian aminopeptidases A and N and leukotriene A., hydrolase,
E. cofi aminopeptidase N and an alanine/arginine aminopeptidase encoded by the AAPl gene …

Membrane protein secretases

NM Hooper, EH KARRAN, AJ TURNER - Biochemical Journal, 1997 - portlandpress.com
… and the N-terminally deleted mutant of human somatic ACE may simply be due to the presence
in human ACE of a potential N-linked glycosylation site eight residues N-terminal to Arg"#…

ADAMs family members as amyloid precursor protein α‐secretases

…, ET Parkin, AJ Turner, NM Hooper - Journal of …, 2003 - Wiley Online Library
In the non‐amyloidogenic pathway, the Alzheimer's amyloid precursor protein (APP) is
cleaved within the amyloid‐β domain by α‐secretase precluding deposition of intact amyloid‐β …

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

…, G Wilcock, S Love, PG Kehoe, NM Hooper… - Nature …, 2011 - nature.com
We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …

[HTML][HTML] A human homolog of angiotensin-converting enzyme: cloning and functional expression as a captopril-insensitive carboxypeptidase

SR Tipnis, NM Hooper, R Hyde, E Karran… - Journal of Biological …, 2000 - ASBMB
… The predicted protein sequence consists of 805 amino acids, including a potential 17-amino
acid N-terminal signal peptide sequence and a putative C-terminal membrane anchor. …

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

…, PJ Grant, AJ Turner, NM Hooper - Biochemical …, 2004 - portlandpress.com
… Surprisingly, we were unable to confirm this observation: Ang (1–7) was cleaved to a
similar extent by both the N- and C-domains of ACE, with N-ACE having a lower affinity, but a …

[HTML][HTML] Tumor necrosis factor-α convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) …

…, P Thornhill, ET Parkin, AI Smith, NM Hooper… - Journal of Biological …, 2005 - ASBMB
… ACE2 is a type I transmembrane protein, with an extracellular N-terminal domain containing
the active site and a short intracellular C-terminal tail. A soluble form of ACE2, lacking its …

A carcinogenic potency database of the standardized results of animal bioassays

…, M De Veciana, R Levinson, NK Hooper… - Environmental …, 1984 - ehp.niehs.nih.gov
The preceding paper described our numerical index of carcinogenic potency, the TD 50 and
the statistical procedures adopted for estimating it from experimental data. This paper …

[HTML][HTML] ACE2: from vasopeptidase to SARS virus receptor

AJ Turner, JA Hiscox, NM Hooper - Trends in pharmacological sciences, 2004 - cell.com
… As with other coronaviruses, it is the N-terminal portion (S1 domain) of the viral spike (S)
glycoprotein that mediates … Human aminopeptidase N is a receptor for human coronavirus 229E. …

The angiotensin–converting enzyme gene family: genomics and pharmacology

AJ Turner, NM Hooper - Trends in pharmacological sciences, 2002 - cell.com
… Originally, this topology of ACE was established by showing that the N-terminal sequences
of affinity-purified, membrane-bound ACE and trypsin-solubilized ACE were identical [ …