Context-dependent biological variation presents a unique challenge to the reproducibility of
results in experimental animal research, because organisms’ responses to experimental …

… This “genetic standardization” enables experimental designs that would be impossible using
outbred animals or humans (monozygotic twins represent n = 2, a sample size that imposes …

… For each analysis, report the exact value of n in each experimental group. … Percie du Sert N,
Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, et al. Reporting animal research: … Karp …

… They used standardized procedures to generate mutant loci for genes of interest in B6 N ES
… Furthermore, the ES cell resources were based on B6 N ES cells; this allows the generation …

: Lengthening of the mandible by gradual distraction was performed on four young patients (average
age 78 months). The amount of mandibular bone lengthening ranged from 18 to 24 …

… ‘The present study used the tissues collected at E15.5 from dams fed the 1X choline and
4X choline diets (n = 3 dams per group, per fetal sex; total n = 12 dams). To ensure statistical …

… Drug-näive schizophrenia patients are denoted by ** (n=7), while minimally treated patients
are marked by * (<6000 lifetime fluphenazine units; n=4). Note that the schizophrenia group …

Mutations in whole organisms are powerful ways of interrogating gene function in a realistic
context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides …

… a clear 24 hr cycle in liver from wild-type animals (n = 6 per time point), with protein levels
peaking in the … All data aree plotted as the mean +SEM (n = 3 for proteins, n = 6 for mRNA). …

iTRAQ (isobaric tags for relative or absolute quantitation) is a mass spectrometry technology
that allows quantitative comparison of protein abundance by measuring peak intensities of …