Interleukin 27 (IL-27) was first characterized as a proinflammatory cytokine with T helper type
1–inducing activity. However, subsequent work has demonstrated that mice deficient in IL-…

The complement system serves an important role in clearance of pathogens, immune complexes,
and apoptotic cells present in the circulation. Complement fragments deposited on the …

… i, Representative bioluminescent images of mice with an orthotopic AKVPSL tumour after
the indicated time and treatment (n = 12 for saline and n = 8 for DT). j, Representative images …

… Approximately 100 fields of view were counted per mouse; n = 3. Lines represent the mean
… Approximately 100 fields of view were counted per mouse; n = 3. Lines represent the mean …

… cells in the bone marrow and spleen of mice (n = 3) from each study arm. (E) Mean weights
(mean ± SEM) of spleen and liver from the mice (n = 3) in the indicated study arms are …

… bispecific antibodies pairing an antibody arm targeting an N-terminal glycprotein D (gD) …
in HT29 cells genetically engineered to harbour an N-terminal luciferase tag 21 (HiBiT) on …

… The p110 catalytic subunits of PI3K share a common domain architecture consisting of an
N-… Similarly, the p85 regulatory subunits have in common an N-terminal SH3 domain, a …

Antibody-drug conjugates (ADC), potent cytotoxic drugs covalently linked to antibodies via
chemical linkers, provide a means to increase the effectiveness of chemotherapy by targeting …

The cytokine IL-27 is important for restricting inflammation in response to a wide variety of
immune challenges. In this study, we demonstrate that IL-27 induces expression of the anti-…

Maturation and selection of high-affinity B cell clones in the germinal center (GC) relies on
support from T follicular helper (T FH ) cells. T FH cells are characterized by their localization …