Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms. Moreover…

… Factors VII, IX, X, and prothrombin, contain an N-terminal Gla domain responsible for targeting
to PS. This domain is also found in the cofactors, Protein S and Protein C. The ∼40 amino…

… Ktistakis; Autophagosome formation from membrane compartments enriched in
phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum . J Cell …

Cells regulate the biophysical properties of their membranes by coordinated synthesis of
different classes of lipids. Here, we identified a highly dynamic feedback mechanism by which …

… We found that neither the N-terminal portion alone nor the C-terminal portion alone was
sufficient for ER localization (unpublished data). Thus, the N-terminal domain together with the C-…

We show that matrices carrying the tethered homologs of natural phosphoinositides can be
used to capture and display multiple phosphoinositide binding proteins in cell and tissue …

Autophagy is a catabolic ‘self-eating' pathway that is emerging as a crucial integration point
in cell physiology. With its own set of genes, the autophagy pathway communicates with …

… Ktistakis; Dynamic association of the ULK1 complex with omegasomes during autophagy …
We concluded that the positively charged residues at the N-terminus of Atg13 are important …

Autophagosome formation requires sequential translocation of autophagy-specific proteins
to membranes enriched in PI3P and connected to the ER. Preceding this, the earliest …