User profiles for N. Landeck
Natalie LandeckPostDoc, NIA/NIH Verified email at nih.gov Cited by 1201 |
Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease
The neuropathological substrate of dementia in patients with Parkinson’s disease is still
under debate, particularly in patients with insufficient alternate neuropathology for other …
under debate, particularly in patients with insufficient alternate neuropathology for other …
Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration
… α-synuclein adenoviruses (multiplicity of infection = 50, 72 h) (*P < 0.05; comparing between
empty vector and high Lamp2a lines transduced with wild-type α-synuclein adenovirus; n = …
empty vector and high Lamp2a lines transduced with wild-type α-synuclein adenovirus; n = …
Association of variants in the SPTLC1 gene with juvenile amyotrophic lateral sclerosis
Importance Juvenile amyotrophic lateral sclerosis (ALS) is a rare form of ALS characterized
by age of symptom onset less than 25 years and a variable presentation. Objective To …
by age of symptom onset less than 25 years and a variable presentation. Objective To …
LRRK2 mediates tubulation and vesicle sorting from lysosomes
… per cell after LLOME (n = 20 cells per N, N = 3). Data are … lysosomes per cell (n = 20 to 30
cells per N, from N = 3). Data … t test with Welch’s correction (n = 13 cells per condition in a …
cells per N, from N = 3). Data … t test with Welch’s correction (n = 13 cells per condition in a …
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies
…, TW Herling, NS Matharu, N Landeck… - EMBO molecular …, 2021 - embopress.org
… Western blotting did not reveal any LAG3-specific bands in non-induced cultures (Fig 1D),
and scRNAseq yielded only minimal counts for the LAG3 transcript in neurons (N), astrocytes (…
and scRNAseq yielded only minimal counts for the LAG3 transcript in neurons (N), astrocytes (…
[HTML][HTML] Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
… (F) Quantitation of the percentage of LRRK2/Rab8a puncta per cell that colocalizes with
either LAMP1 or Pericentrin (N > 19 cells for each condition from 2 independent experiments; …
either LAMP1 or Pericentrin (N > 19 cells for each condition from 2 independent experiments; …
Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory-and oxidative stress-related pathways upon treatment with α-synuclein …
… The results are expressed as the mean ± SE (n = 3 per each group). Data were analyzed …
The results are expressed as the mean ± SE (n = 3 per each group). Data were analyzed using …
The results are expressed as the mean ± SE (n = 3 per each group). Data were analyzed using …
Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes
The progressive neuropathological damage seen in Parkinson's disease (PD) is thought to
be related to the spreading of aggregated forms of α‐synuclein. Clearance of extracellular α‐…
be related to the spreading of aggregated forms of α‐synuclein. Clearance of extracellular α‐…
Rapid, reproducible transduction of select forebrain regions by targeted recombinant virus injection into the neonatal mouse brain
N Pilpel, N Landeck, M Klugmann, PH Seeburg… - Journal of neuroscience …, 2009 - Elsevier
… infused according to our experimentally defined coordinates into the lateral ventricles (n
= 10 mice), hippocampus (n = 8 mice) or cerebellum (1 μl; n = 6 mice) of neonates at 125 nl/s …
= 10 mice), hippocampus (n = 8 mice) or cerebellum (1 μl; n = 6 mice) of neonates at 125 nl/s …
[HTML][HTML] A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein
… To do so, we lysed frontal cortex tissue samples from healthy controls (n = 16) using buffer
… in samples obtained from healthy controls (Ctrl) (n = 8 per group). We acquired four different …
… in samples obtained from healthy controls (Ctrl) (n = 8 per group). We acquired four different …