User profiles for N. Lawlor

Nathan Lawlor

- Verified email at 2seventybio.com - Cited by 1328

Nathan Lawler

- Verified email at murdoch.edu.au - Cited by 770

[HTML][HTML] Human milk components modulate toll-like receptor–mediated inflammation

YY He, NT Lawlor, DS Newburg - Advances in Nutrition, 2016 - Elsevier
… Also, pioneer bacterial colonization stimulates extracellular signal-regulated kinase (ERK)
and c-Jun N-terminal kinase signaling pathways. Amplified ERK and c-Jun N-terminal kinase …

Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes

N Lawlor, J George, M Bolisetty, R Kursawe… - Genome …, 2017 - genome.cshlp.org
… less than 3500 genes (n = 72) were removed from downstream analyses. (D) Scatter plot
comparing intact islet bulk RNA-seq (n = 8) and ensemble single-cell RNA-seq (n = 978) data …

Genomics of islet (dys) function and type 2 diabetes

N Lawlor, S Khetan, D Ucar, ML Stitzel - Trends in Genetics, 2017 - cell.com
Pancreatic islet dysfunction and beta cell failure are hallmarks of type 2 diabetes mellitus (T2DM)
pathogenesis. In this review, we discuss how genome-wide association studies (…

The human milk oligosaccharide 2′-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation

YY He, SB Liu, DE Kling, S Leone, NT Lawlor, Y Huang… - Gut, 2016 - gut.bmj.com
… CD14 in T84 culture supernatants increased (n=6). (D) After incubation with 2′-FL,
membrane-bound CD14 relocated into cytoplasm in basal and LPS-treated T84 cells (n=8). (E) H4 …

[HTML][HTML] Metabolomics and lipidomics: expanding the molecular landscape of exercise biology

MR Belhaj, NG Lawler, NJ Hoffman - Metabolites, 2021 - mdpi.com
… Recently, it was demonstrated that vasoactive lipids derived from the n-3 and n-6
polyunsaturated FA (PUFA) and metabolized by CYP were also released into the bloodstream …

[HTML][HTML] AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

A Thibodeau, A Eroglu, CS McGinnis, N Lawlor… - Genome biology, 2021 - Springer
Detecting multiplets in single nucleus (sn)ATAC-seq data is challenging due to data sparsity
and limited dynamic range. AMULET (ATAC-seq MULtiplet Estimation Tool) enumerates …

[PDF][PDF] Multiomic profiling identifies cis-regulatory networks underlying human pancreatic β cell identity and function

N Lawlor, EJ Marquez, P Orchard, N Narisu… - Cell reports, 2019 - cell.com
… Interestingly, we observed a substantial number of EndoC-bH1 enhancers that were annotated
as quiescent or repressed in islets (n = 19,380) (Figure 2D, orange box). Relative to all …

Type 2 diabetes–associated genetic variants regulate chromatin accessibility in human islets

S Khetan, R Kursawe, A Youn, N Lawlor, A Jillette… - Diabetes, 2018 - Am Diabetes Assoc
… (n = 1,515) were calculated against all OCRs used in differential analysis (n = 52,387). …
OCRs (n = 52,387) and differentially accessible OCRs (n = 1,515), further separated into closing (…

[HTML][HTML] Single cell analysis of blood mononuclear cells stimulated through either LPS or anti-CD3 and anti-CD28

N Lawlor, D Nehar-Belaid, JDS Grassmann… - Frontiers in …, 2021 - frontiersin.org
Immune cell activation assays have been widely used for immune monitoring and for
understanding disease mechanisms. However, these assays are typically limited in scope. A …

Incomplete systemic recovery and metabolic phenoreversion in post-acute-phase nonhospitalized COVID-19 patients: implications for assessment of post-acute …

…, M Spraul, H Schaefer, NG Lawler, N Gray… - Journal of proteome …, 2021 - ACS Publications
… Metabolic data for the follow-up patients (n = 27) were compared with controls (n = 41) and
hospitalized severe acute respiratory syndrome SARS-CoV-2 positive patients (n = 18, with …