Suppression of TH2-type allergic reactions by helminth infection
There is no immunological mechanism to adequately explain the sudden epidemic in allergies
noted in the last 30 years in developed countries. The reduction in the development of …
noted in the last 30 years in developed countries. The reduction in the development of …
Interferon-ε protects the female reproductive tract from viral and bacterial infection
The innate immune system senses pathogens through pattern-recognition receptors (PRRs)
that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized …
that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized …
Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
… We infected il25 −/− mice and wild-type controls with N. brasiliensis and monitored for worm
burden and type 2 effector functions. The wild-type and il25 −/− mice displayed very similar …
burden and type 2 effector functions. The wild-type and il25 −/− mice displayed very similar …
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming
…, LE Campbell, SP Saunders, NE Mangan… - Nature …, 2009 - nature.com
… Exon 1 consists of 5′-UTR sequences only; exon 2 contains the ATG and encodes part
of the N-terminal S100 calcium-binding domain of profilaggrin; and exon 3 encodes the …
of the N-terminal S100 calcium-binding domain of profilaggrin; and exon 3 encodes the …
Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape
Breast cancer metastasis is a key determinant of long-term patient survival. By comparing
the transcriptomes of primary and metastatic tumor cells in a mouse model of spontaneous …
the transcriptomes of primary and metastatic tumor cells in a mouse model of spontaneous …
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model
BACKGROUND: Parasitic helminth infections of humans have been shown to suppress the
immune response to allergens. Experimentally, infection of mice with the helminth …
immune response to allergens. Experimentally, infection of mice with the helminth …
The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis
EP Cummins, F Seeballuck, SJ Keely, NE Mangan… - Gastroenterology, 2008 - Elsevier
BACKGROUND & AIMS: Prolyl and asparaginyl hydroxylases are key oxygen-sensing
enzymes that confer hypoxic sensitivity to transcriptional regulatory pathways including the …
enzymes that confer hypoxic sensitivity to transcriptional regulatory pathways including the …
Inferring biological networks by sparse identification of nonlinear dynamics
… Second, we calculate a matrix, N, with columns spanning the null space of . We wish to find
the linear combinations of columns in N that produces a sparse vector ξ. For this third step, …
the linear combinations of columns in N that produces a sparse vector ξ. For this third step, …
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
…, AM Ellisdon, B Rotter, T Azam, NE Mangan… - Nature …, 2015 - nature.com
Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of
the IL-1 ligand family and IL-1 receptor family, respectively. Here we demonstrate formation …
the IL-1 ligand family and IL-1 receptor family, respectively. Here we demonstrate formation …
Helminth infection protects mice from anaphylaxis via IL-10-producing B cells
NE Mangan, RE Fallon, P Smith… - The Journal of …, 2004 - journals.aai.org
Modulation of the immune system by infection with helminth parasites, including schistosomes,
is proposed to reduce the levels of allergic responses in infected individuals. In this study …
is proposed to reduce the levels of allergic responses in infected individuals. In this study …