User profiles for N. Merle

nicolas MERLE

NIH
Verified email at nih.gov
Cited by 3476

[HTML][HTML] Complement system part I–molecular mechanisms of activation and regulation

NS Merle, SE Church, V Fremeaux-Bacchi… - Frontiers in …, 2015 - frontiersin.org
Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …

[HTML][HTML] Complement system part II: role in immunity

NS Merle, R Noe, L Halbwachs-Mecarelli… - Frontiers in …, 2015 - frontiersin.org
… In plasma, C3a and C5a are quickly converted by carboxypeptidase N and carboxypeptidase
B into C3a-desArg and C5a-desArg, by cleavage of the C-terminal arginine (74–76). …

Tumor cells hijack macrophage-produced complement C1q to promote tumor growth

…, J Meilleroux, BL Clec'h, NA Giraldo, NS Merle… - Cancer immunology …, 2019 - AACR
… Prognostic value of C1q+ cells on PFS of patients from Cohort 2 (n = 154) with localized
stages I–II (E) and advanced stages III–IV (F). G, PFS and OS of Cohort 3 (n = 43) patients with …

Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation

…, N Kunz, EE West, T Freiwald, JV Desai, NS Merle… - Science …, 2021 - science.org
… at 4 hours after activation by Seahorse analysis (n = 11). (I) Effect … n = 3). (J) Mitochondrial
mass in resting and activated monocytes with or without PMX53 or JPE1375 preincubation (n

The AAA+ ATPase ATAD3A Controls Mitochondrial Dynamics at the Interface of the Inner and Outer Membranes

…, O Gay, N Merle, N Assard… - … and cellular biology, 2010 - Taylor & Francis
… The N-terminal domain interacts with the OM. A central transmembrane segment (TMS) …
mutant and a truncated 50-amino-acid N-terminus mutant, we showed that ATAD3A regulates …

[HTML][HTML] Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles

NS Merle, A Grunenwald, H Rajaratnam, V Gnemmi… - JCI insight, 2018 - ncbi.nlm.nih.gov
… On light microscopy, the predominant pattern of the observed glomerular disease was
specific SCD glomerulopathy (n = 5), focal segmental glomerulosclerosis (n = 3), …

Complement's favourite organelle—Mitochondria?

…, P Singh, NS Merle, N Niyonzima… - British Journal of …, 2021 - Wiley Online Library
The complement system, well known for its central role in innate immunity, is currently emerging
as an unexpected, cell‐autonomous, orchestrator of normal cell physiology. Specifically, …

[PDF][PDF] Systematic single-cell pathway analysis to characterize early T cell activation

JA Bibby, D Agarwal, T Freiwald, N Kunz, NS Merle… - Cell reports, 2022 - cell.com
Pathway analysis is a key analytical stage in the interpretation of omics data, providing a
powerful method for detecting alterations in cellular processes. We recently developed a …

P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner

NS Merle, R Paule, J Leon, M Daugan… - Proceedings of the …, 2019 - National Acad Sciences
… The prevention of C5a release indicated that the Ab exerted its blocking effect (n ≥ 4). (F)
ALT activity levels (FC) or (G) quantification of the percentage of NGAL positive area in the …

Heteronuclear NMR Spectroscopy as a Surface‐Selective Technique: A Unique Look at the Hydroxyl Groups of γ‐Alumina.

M Taoufik, KC Szeto, N Merle, ID Rosal… - … A European Journal, 2014 - Wiley Online Library
The surface hydroxyl groups of γ‐alumina dehydroxylated at 500 C were studied by a
combination of one‐ and two‐dimensional homo‐ and heteronuclear 1 H and 27 Al NMR …